被捕：休眠中的胚胎。
Under Arrest: The Embryo in Diapause.
机构信息
Centre de Recherche en Reproduction et Fertilité, Université de Montréal, St-Hyacinthe, QC J2S2M2 Canada.
出版信息
Dev Cell. 2020 Jan 27;52(2):139-140. doi: 10.1016/j.devcel.2020.01.002.
PMID:31991103
Abstract
Embryonic diapause is the reversible arrest in development of mammalian embryos at the blastocyst stage. In this issue of Developmental Cell, Hussein et al. (2020) reveal that alternative splicing of Lkb1 is essential for diapause to persist and find the elevation of glycolytic and lipolytic pathways that were previously considered dormant.
摘要
胚胎休眠是指哺乳动物胚胎在囊胚阶段发育的可逆停滞。在本期《发育细胞》中，Hussein 等人（2020）揭示了 Lkb1 的可变剪接对于休眠的持续至关重要，并发现了以前被认为处于休眠状态的糖酵解和脂解途径的升高。
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