动脉粥样硬化中的IgM天然抗体T15/E06
IgM natural antibody T15/E06 in atherosclerosis.
作者信息
Zou Jin, Wang Gang, Li Heng, Yu Xiaohua, Tang Chaoke
机构信息
Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Medical Research Experiment Center, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, Department of Cardiology, The First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan 421001, China.
Institute of Clinical Medicine, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan 460106, China.
出版信息
Clin Chim Acta. 2020 May;504:15-22. doi: 10.1016/j.cca.2020.01.024. Epub 2020 Jan 25.
Atherosclerosis is regarded as a lipid-driven chronic inflammatory disease. A variety of immune cells, including B1 cells, play an important role in the occurrence and development of atherosclerosis. T15/E06 is an IgM Nab secreted by B1 cells. The concentration of T15/E06 is significantly decreased in animal models of atherosclerosis. Accumulating evidence has shown that T15/E06 can protect against atherosclerosis by blocking macrophage lipid uptake, inhibiting vascular inflammation, and promoting apoptotic cell clearance. In this review, we describe the structure, functions and regulation of T15/E06 and summarize the latest advance regarding its atheroprotective effect.
动脉粥样硬化被视为一种脂质驱动的慢性炎症性疾病。包括B1细胞在内的多种免疫细胞在动脉粥样硬化的发生和发展中起重要作用。T15/E06是一种由B1细胞分泌的IgM抗体。在动脉粥样硬化动物模型中，T15/E06的浓度显著降低。越来越多的证据表明，T15/E06可通过阻断巨噬细胞脂质摄取、抑制血管炎症和促进凋亡细胞清除来预防动脉粥样硬化。在这篇综述中，我们描述了T15/E06的结构、功能和调节，并总结了其抗动脉粥样硬化作用的最新进展。
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