Center for Medical Informatics, Yale University School of Medicine, New Haven, CT, 06511, USA.
Department of Genetics, Yale University School of Medicine, New Haven, CT, 06520-8005, USA.
Forensic Sci Int Genet. 2020 May;46:102237. doi: 10.1016/j.fsigen.2020.102237. Epub 2020 Jan 22.
The web-based application, FROG-kb (the Forensic Resource/Reference on Genetics-knowledge base, https://frog.med.yale.edu) supports the use of Single Nucleotide Polymorphisms (SNPs) for individual identification and ancestry inference in a forensic setting. The primary functionality provided by FROG-kb on the web is computation of relative likelihoods of populations being the origin of an individual, utilizing the underlying reference population allele frequency data curated and organized in ALFRED, the ALlele FREquency Database (https://alfred.med.yale.edu/). Here we present a downloadable stand-alone tool, FrogAncestryCalc that can simultaneously compute population likelihoods for multiple individuals for a selected panel of SNPs. The program calculates for a given Ancestry Inference (AI) panel the probability of each individual's genotype profile arising in each of the reference populations. Five of the AI panels catalogued in FROG-kb are implemented in this version of FrogAncestryCalc.
基于网络的应用程序 FROG-kb（法医资源/遗传学知识库，https://frog.med.yale.edu）支持在法医环境中使用单核苷酸多态性（SNPs）进行个体识别和祖先推断。FROG-kb 在网络上提供的主要功能是计算个体起源的人群相对可能性，利用在 ALFRED（ALlele FREquency Database，https://alfred.med.yale.edu/）中 curated 和组织的基础参考人群等位基因频率数据。在这里，我们介绍一个可下载的独立工具 FrogAncestryCalc，它可以同时为选定的 SNPs 面板计算多个个体的人群可能性。该程序为给定的祖先推断 (AI) 面板计算每个个体基因型在每个参考人群中出现的概率。FROG-kb 中编目的五个 AI 面板在这个版本的 FrogAncestryCalc 中实现。
