Cakir Murat, Sag Elif, Saygin Ismail, Orhan Fazil
Department of Pediatric Gastroenterology Hepatology and Nutrition, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey,
Department of Pediatric Gastroenterology Hepatology and Nutrition, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.
Med Princ Pract. 2020;29(5):473-479. doi: 10.1159/000506257. Epub 2020 Jan 31.
We aimed to share our observations on the demographics, clinical characteristics, and outcomes of lymphonodular hyperplasia (LNH) in children.
The study included children on whom colonoscopy was performed between January 2015 and May 2018 (n = 361). Demographics, treatment modalities, and outcomes of the patients with LNH were recorded.
LNH was found in 66 patients (18.3%; mean age 8.6 ± 5.96 years, 59.1% male). We found that the etiologic factors were food hypersensitivity (FH) in 25 (37.8%), nonspecific colitis in 12 (18.2%), irritable bowel syndrome in 10 (15.2%), familial Mediter-ranean fever in 7 (10.6%), primary immunodeficiency in 4 (6.1%), and intestinal dysmotility, oxyuriasis, Crohn's disease, and giardiasis in 1 (1.5%) patient. Additionally, in the genetic analysis of patients with idiopathic LNH (n = 4), we detected heterozygote MEFV mutations in all. Cow's milk and egg (25%) were the most common allergens in patients with FH. Symptoms of all patients (n = 25) improved after an elimination diet.
LNH is a common finding in pediatric colonoscopies with a variety of etiologies ranging from FH and familial Mediterranean fever to immunodeficiency.
我们旨在分享关于儿童淋巴小结增生（LNH）的人口统计学特征、临床特征及结局的观察结果。
本研究纳入了2015年1月至2018年5月期间接受结肠镜检查的儿童（n = 361）。记录了LNH患者的人口统计学特征、治疗方式及结局。
66例患者（18.3%；平均年龄8.6±5.96岁，59.1%为男性）被发现患有LNH。我们发现病因如下：食物过敏（FH）25例（37.8%）、非特异性结肠炎12例（18.2%）、肠易激综合征10例（15.2%）、家族性地中海热7例（10.6%）、原发性免疫缺陷4例（6.1%），以及1例（1.5%）患者存在肠道动力障碍、蛲虫病、克罗恩病和贾第虫病。此外，在特发性LNH患者（n = 4）的基因分析中，我们在所有患者中均检测到杂合子MEFV突变。牛奶和鸡蛋（25%）是FH患者中最常见的过敏原。所有患者（n = 25）在进行排除饮食后症状均有改善。
LNH在儿科结肠镜检查中是一种常见发现，其病因多样，从FH和家族性地中海热到免疫缺陷不等。
