Department of Health Sciences, Carleton University, Ottawa, Canada.
Centre Armand-Frappier Santé Biotechnologie, Institut national de la recherche scientifique, Université du Québec, Laval, Canada.
J Med Screen. 2020 Dec;27(4):215-222. doi: 10.1177/0969141320902485. Epub 2020 Jan 30.
If prostate cancer screening practices relate to occupation, this would have important implications when studying the aetiological role of workplace exposures on prostate cancer. We identified variations in screening by occupation among men in Montreal, Canada (2005-2012).
Prostate specific antigen testing and digital rectal examination (ever-screened and frequency of screening, previous five years) were examined among population controls from the . Face-to-face interviews elicited lifestyle and occupational histories. Multivariable logistic regression was used to estimate the odds of ever-screening for the longest-held occupation, adjusting for potential confounders. Negative binomial models were used to examine relationships with screening frequency.
Among 1989 controls, 81% reported ever having had a prostate specific antigen test, and 77% a digital rectal examination. Approximately 40% of men reported having a prostate specific antigen test once a year, on average. Compared with those in management or administrative jobs, men in primary industry (odds ratio 0.26, 95% confidence interval 0.10-0.65), construction (0.44, 0.25-0.79), machining (0.45, 0.21-0.97), and teaching (0.37, 0.20-0.70) were less likely to have undergone prostate specific antigen screening. Results were similar when considering the most recent job.
Our findings highlight substantial variations in prostate cancer screening by occupation. Men in occupations where carcinogen exposures are more common are less likely to participate in prostate screening activities. This could be an important source of bias, and occupational studies of prostate cancer should account for screening practices.
如果前列腺癌筛查实践与职业有关，那么在研究工作场所暴露对前列腺癌病因学作用时，这将具有重要意义。我们在加拿大蒙特利尔（2005-2012 年）的人群对照中确定了不同职业的前列腺癌筛查情况。
对人群对照的前列腺特异性抗原检测和直肠指检（既往筛查和筛查频率，过去五年）进行了检测。面对面访谈收集了生活方式和职业史。多变量逻辑回归用于估计最长持有的职业的筛查概率，同时调整潜在的混杂因素。负二项模型用于检验与筛查频率的关系。
在 1989 名对照者中，81%的人报告曾进行过前列腺特异性抗原检测，77%的人进行过直肠指检。平均而言，约 40%的男性报告每年进行一次前列腺特异性抗原检测。与从事管理或行政工作的男性相比，从事第一产业（比值比 0.26，95%置信区间 0.10-0.65）、建筑（0.44，0.25-0.79）、机械加工（0.45，0.21-0.97）和教学（0.37，0.20-0.70）的男性进行前列腺特异性抗原筛查的可能性较低。当考虑最近的工作时，结果相似。
我们的研究结果突出了职业对前列腺癌筛查的显著差异。在致癌物暴露更为常见的职业中，男性参与前列腺癌筛查的可能性较低。这可能是一个重要的偏倚来源，前列腺癌的职业研究应考虑筛查实践。
