Almeneessie Aljohara S, Alyousefi Nada, Alzahrani Maha, Alsafi Aisha, Alotaibi Raneem, Olaish Awad H, Sabr Yasser, Bahammam Ahmed S
Department of Medicine, The University Sleep Disorders Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Ann Thorac Med. 2020 Jan-Mar;15(1):9-14. doi: 10.4103/atm.ATM_206_19. Epub 2020 Jan 2.
This cross-sectional case-control study aimed to assess the prevalence of restless legs syndrome (RLS) and its correlates and severity among Arab (Saudi) pregnant women attending antenatal care clinics.
We interviewed 742 consecutive pregnant women attending antenatal clinics face-to-face using the International RLS Study Group (IRLSSG) criteria. We assessed the severity of RLS using the IRLSSG severity scale for RLS (IRLS). A similar number of age-matched nonpregnant women were enrolled in a control group.
Among the cases, 104 (14%) were in the first trimester, 232 (31.3%) in the second trimester, and 406 (54.7%) in the third trimester. The RLS prevalence in cases and controls was 30% and 26.5%, respectively, ( = 0.134). Among cases, severe/very severe RLS was diagnosed in 25% and mild/moderate in 75%, compared with 15% of controls having severe/very severe RLS and 85% having mild/moderate RLS ( < 0.001). Multivariate binary logistic regression analysis identified the following parameters as independent predictors of RLS: parity (odds ratio [OR] 1.113 [confidence intervals [CI] 1.012-1.223], = 0.027), anemia (OR 1.452 [1.033-2.042], = 0.03), diabetes mellitus (OR 1.734 [CI 1.084-2.774], = 0.022), Vitamin D deficiency (OR 2.376 [CI 1.488-3.794], < 0.001), and smoking (OR 3.839 [CI 1.463-10.074], = 0.006). None of the cases had been diagnosed or treated for RLS in the antenatal clinics.
RLS is common, but underdiagnosed, among Saudi pregnant women and nonpregnant women of childbearing age. The study revealed that RLS during pregnancy is linked to parity, anemia, diabetes mellitus, Vitamin D deficiency, and smoking.
这项横断面病例对照研究旨在评估在产前保健诊所就诊的阿拉伯（沙特）孕妇中不安腿综合征（RLS）的患病率及其相关因素和严重程度。
我们使用国际不安腿综合征研究组（IRLSSG）标准对742名连续就诊于产前诊所的孕妇进行了面对面访谈。我们使用IRLSSG不安腿综合征严重程度量表（IRLS）评估RLS的严重程度。对照组纳入了数量相似的年龄匹配非孕妇。
在病例组中，104名（14%）处于孕早期，232名（31.3%）处于孕中期，406名（54.7%）处于孕晚期。病例组和对照组中RLS的患病率分别为30%和26.5%（P = 0.134）。在病例组中，25%被诊断为重度/极重度RLS，75%为轻度/中度RLS，而对照组中15%为重度/极重度RLS，85%为轻度/中度RLS（P < 0.001）。多因素二元逻辑回归分析确定了以下参数为RLS的独立预测因素：产次（比值比[OR] 1.113 [置信区间[CI] 1.012 - 1.223]，P = 0.027）、贫血（OR 1.452 [1.033 - 2.042]，P = 0.03）、糖尿病（OR 1.734 [CI 1.084 - 2.774]，P = 0.022）、维生素D缺乏（OR 2.376 [CI 1.488 - 3.794]，P < 0.001）和吸烟（OR 3.839 [CI 1.
