Clínica Psiquiátrica Universitaria, Facultad Medicina Universidad de Chile, Santiago, Chile; Department of Psychiatry, Tufts University, School of Medicine, Tufts Medical Center, Pratt Building, 3rd Floor, 800 Washington Street, Box 1007, Boston, MA 02111, USA.
Department of Psychiatry, Tufts University, School of Medicine, Tufts Medical Center, Pratt Building, 3rd Floor, 800 Washington Street, Box 1007, Boston, MA 02111, USA; Department of Psychiatry, Harvard Medical School, Harvard University, Boston, MA, USA.
Psychiatr Clin North Am. 2020 Mar;43(1):27-46. doi: 10.1016/j.psc.2019.10.003. Epub 2019 Dec 19.
Mixed states are frequent clinical pictures in psychiatric practice but are not well described in nosologic systems. Debate exists as to defining mixed states. We review factor and cluster analytical studies and prominent clinical/conceptual models of mixed states. While mania involves standard manic symptoms and depression involves standard depressive symptoms, core additional features of the mixed state are, primarily, psychomotor activation and, secondarily, dysphoria. Those features are more pronounced in mixed mania than in mixed depression but are present in both.
混合状态在精神科临床中较为常见,但在疾病分类系统中描述不佳。关于混合状态的定义存在争议。我们回顾了混合状态的因素和聚类分析研究以及突出的临床/概念模型。虽然躁狂症涉及标准的躁狂症状,抑郁症涉及标准的抑郁症状,但混合状态的核心附加特征主要是精神运动激活,其次是烦躁不安。这些特征在混合躁狂症中比在混合抑郁症中更为明显,但在两者中都存在。