Fite Paula J, Brown Shaquanna, Hossain Waheeda A, Manzardo Ann, Butler Merlin G, Bortolato Marco
Consortium for Translational Research on Aggression and Drug Abuse (ConTRADA), University of Kansas, Lawrence, KS, United States.
Clinical Child Psychology Program, University of Kansas, Lawrence, KS, United States.
Front Genet. 2020 Jan 17;10:1314. doi: 10.3389/fgene.2019.01314. eCollection 2019.
Polysubstance use (PSU) is highly prevalent among college students. Recent evidence indicates that PSU is based on gene x environment (G×E) interactions, yet the specific biosocial factors underlying this problem remain elusive. We recently reported that lifetime use of tobacco and cannabis in college students is influenced by the interaction of the X-linked (monoamine oxidase A) gene and child maltreatment. Building on these premises, here we evaluated whether the same G×E interaction may also predict PSU in this population. Students of a large Midwestern university (n = 470; 50.9% females) took part in a computer survey for substance use, as well as childhood trauma exposure, using the Child Trauma Questionnaire (CTQ). DNA was extracted from their saliva samples and genotyped for variable-number of tandem repeat (VNTR) variants. Findings indicated that the highest number of substances were used by male students harboring low-activity alleles with a history of childhood emotional abuse. In contrast, female homozygous high-activity carriers with a history of emotional and physical abuse reported consumption of the greatest number of substances. Our results indicate that PSU among college students is influenced by the interaction of and child maltreatment in a sex-specific fashion. Further studies are warranted to understand the mechanisms of sex differences in the biosocial interplays underlying PSU in this at-risk group.
多物质使用（PSU）在大学生中非常普遍。最近的证据表明，PSU基于基因与环境（G×E）的相互作用，但这个问题背后的具体生物社会因素仍然难以捉摸。我们最近报告称，大学生一生中使用烟草和大麻受到X连锁（单胺氧化酶A）基因与儿童期虐待的相互作用的影响。基于这些前提，我们在此评估了相同的G×E相互作用是否也能预测该人群中的PSU。一所大型中西部大学的学生（n = 470；50.9%为女性）使用儿童创伤问卷（CTQ）参与了一项关于物质使用以及童年创伤暴露的计算机调查。从他们的唾液样本中提取DNA，并对可变数目串联重复（VNTR）变体进行基因分型。研究结果表明，携带低活性等位基因且有童年情感虐待史的男学生使用的物质数量最多。相比之下，有情感和身体虐待史的女性纯合高活性携带者报告使用的物质数量最多。我们的结果表明，大学生中的PSU受到[此处原文可能缺失相关基因信息]与儿童期虐待的相互作用的性别特异性影响。有必要进行进一步研究，以了解这一高危群体中PSU背后生物社会相互作用中性别差异的机制。
