Son Ye-Eun, Park Hee-Soo
School of Food Science and Biotechnology, Institute of Agricultural Science and Technology, Kyungpook National University, Daegu, South Korea.
Mycobiology. 2019 Oct 22;47(4):457-465. doi: 10.1080/12298093.2019.1677380. eCollection 2019.
MonA is a subunit of a guanine nucleotide exchange factor that is important for vacuole passing and autophagy processes in eukaryotes. In this study, we characterized the function of MonA, an orthologue of Mon1, in the model fungus and a toxigenic fungus . In , the absence of led to decreased fungal growth, reduced asexual reproduction, and defective cleistothecia production. In addition, deletion mutants exhibited decreased spore viability, had reduced trehalose contents in conidia, and were sensitive to thermal stress. In , deletion of caused decreased fungal growth and defective production of asexual spores and sclerotia structures. Moreover, the absence of affected vacuole morphology in both species. Taken together, these results indicate that MonA plays conserved roles in controlling fungal growth, development and vacuole morphology in and .
MonA是一种鸟嘌呤核苷酸交换因子的亚基，对真核生物中的液泡通过和自噬过程很重要。在本研究中，我们在模式真菌和产毒真菌中表征了Mon1的直系同源物MonA的功能。在（此处原文缺失具体真菌名称）中，MonA的缺失导致真菌生长减少、无性繁殖降低以及闭囊壳产生缺陷。此外，MonA缺失突变体表现出孢子活力下降、分生孢子中海藻糖含量降低，并且对热胁迫敏感。在（此处原文缺失具体真菌名称）中，MonA的缺失导致真菌生长减少以及无性孢子和菌核结构产生缺陷。此外，MonA的缺失影响了这两个物种中的液泡形态。综上所述，这些结果表明MonA在控制（此处原文缺失具体真菌名称）和（此处原文缺失具体真菌名称）的真菌生长、发育和液泡形态方面发挥着保守作用。
