足月儿出生后7年内的脑疾病：一项队列研究。
Cerebral disorders in the first 7 years of life in children born post-term: a cohort study.
作者信息
Rolschau Anne Hald, Olesen Annette Wind, Obel Carsten, Olsen Jørn, Wu Chunsen S, Kofoed Poul-Erik
机构信息
Department of Gynecology and Obstetrics, Lillebaelt Hospital, Kolding, Denmark.
Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.
出版信息
BMC Pediatr. 2020 Feb 3;20(1):51. doi: 10.1186/s12887-020-1950-4.
BACKGROUND
To estimate the association between post-term delivery and risk of physical disabilities, mental disabilities, and seizures during the first 7 years of life.
METHODS
Data from 57,884 singleton infants born alive in week 39-45 by mothers included in the Danish National Birth Cohort (1997 to 2004) were analyzed, of these 51,268 were born at term (39-41 + 6) and 6616 post-term (42 + 0-44 + 6). Information on clinical endpoints was obtained from an interview at 18 months of gestational age, from a 7-year questionnaire, and from the Danish National Patient Register. Logistic regression and Cox regression were used to estimate odds ratios and hazard rate ratios for the outcome obtained from the interview/questionnaire data and from the register-based data, respectively.
RESULTS
We found no statistically significant increased risk of physical disabilities, mental disabilities, and epilepsy among children born post-term, though for most outcomes studied a tendency towards more adverse outcomes was seen. When children born late term (week 41) were compared to children born in week 42 or later the same tendency was found.
CONCLUSION
Post-term born children had a tendency to an excess risk of neurological disabilities as followed for up to 7 years of age.
背景
评估过期产与出生后7年内身体残疾、智力残疾和癫痫发作风险之间的关联。
方法
对丹麦国家出生队列（1997年至2004年）中母亲在第39至45周出生的57,884名单胎活产婴儿的数据进行分析，其中51,268名婴儿为足月儿（39 - 41 + 6周），6616名婴儿为过期产儿（42 + 0 - 44 + 6周）。临床终点信息来自孕18个月时的访谈、7岁时的问卷调查以及丹麦国家患者登记处。分别使用逻辑回归和Cox回归来估计从访谈/问卷调查数据和基于登记处的数据中获得的结局的比值比和风险率比。
结果
我们发现过期产儿出现身体残疾、智力残疾和癫痫的风险在统计学上没有显著增加，尽管在所研究的大多数结局中，存在更不利结局的趋势。将晚期足月儿（第41周出生）与第42周或更晚出生的儿童进行比较时，发现了相同的趋势。
结论
在随访至7岁时，过期产儿有出现神经残疾风险增加的趋势。
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