利多卡因过量后的临床反应以及血浆总浓度和游离浓度

Clinical response and total and unbound plasma concentrations after lidocaine overdose.

作者信息

Armstrong D K, Bremseth D L, Lima J J

机构信息

Laboratory of Applied Pharmacokinetics, University of Southern California School of Medicine, Los Angeles.

出版信息

Ther Drug Monit. 1988;10(4):499-500. doi: 10.1097/00007691-198804000-00022.

DOI:10.1097/00007691-198804000-00022

PMID:3201537

Abstract

Plasma and unbound concentrations and hemodynamic and CNS effects were monitored in a patient after overdose of 2 g of lidocaine HCl infused during 1 h. Hypotension, decreased heart rate, tremors, and nonresponsiveness to stimuli were observed at plasma and unbound concentrations of 17.7 and 12.0 micrograms/ml. The half-lives of decline of plasma and unbound concentrations were 3.8 and 2.7 h; the difference in half-lives was due to nonlinear plasma protein binding.

摘要

对一名在1小时内输注2克盐酸利多卡因过量的患者进行了血浆和游离浓度以及血流动力学和中枢神经系统效应监测。在血浆和游离浓度分别为17.7微克/毫升和12.0微克/毫升时，观察到低血压、心率下降、震颤以及对刺激无反应。血浆和游离浓度下降的半衰期分别为3.8小时和2.7小时；半衰期的差异归因于血浆蛋白结合的非线性。