Department of Dermatology and Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Cytometry B Clin Cytom. 2021 Mar;100(2):129-131. doi: 10.1002/cyto.b.21870. Epub 2020 Feb 4.
Flow cytometry of peripheral blood has become the standard tool for the diagnosis and monitoring of Sézary syndrome. However, there is a sense of frustration among dermatologists and oncologist regarding the challenges in interpreting vague flow cytometry (FC) reports, which often include an array of numbers and percentages that are difficult to interpret and fail to elucidate quantitatively or qualitatively the presence or absence of an abnormal T cell population. From the clinicians' perspective, a report of the flow cytometric evaluation for Sézary syndrome should include the following items: presence or absence of abnormal T-cells, phenotype of abnormal cells, and quantity of abnormal cells to disease burden and for staging.
外周血流式细胞术已成为诊断和监测蕈样肉芽肿的标准工具。然而，皮肤科医生和肿瘤学家对于解读模糊的流式细胞术报告感到沮丧，因为这些报告通常包含一系列难以解释的数字和百分比，并且无法定量或定性地阐明异常 T 细胞群的存在与否。从临床医生的角度来看，蕈样肉芽肿的流式细胞术评估报告应包括以下内容：异常 T 细胞的存在与否、异常细胞的表型以及异常细胞的数量与疾病负担和分期的关系。
