Steinman Gary, Mankuta David
Dept. of Obstetrics & Gynecology, Hadassah Hospital - Hebrew University, Ein Kerem, Jerusalem 12000, Israel.
Dept. of Obstetrics & Gynecology, Hadassah Hospital - Hebrew University, Ein Kerem, Jerusalem 12000, Israel.
Med Hypotheses. 2020 May;138:109604. doi: 10.1016/j.mehy.2020.109604. Epub 2020 Jan 27.
Previous reports in this series point to insufficient insulin-like growth factor-1 (IGF1) in the newborn as the key to brain dysconnectivity characteristic of autism. Such a deficiency should be detectable in the baby's blood at or soon after birth. Breast-feeding exclusively for the first year of postpartum life or supplementation with oral agents to raise the serum IGF1 level, such a cyclo-glycylproline, could be helpful for this purpose.
本系列之前的报告指出,新生儿体内胰岛素样生长因子-1(IGF1)不足是自闭症所特有的大脑连接异常的关键。这种缺陷在出生时或出生后不久应该可以在婴儿血液中检测到。产后第一年纯母乳喂养或补充口服制剂以提高血清IGF1水平,如环甘氨酰脯氨酸,可能对此有帮助。