用于肿瘤正电子发射断层扫描和内放射治疗的放射性标记肽
Radiolabelled Peptides for Positron Emission Tomography and Endoradiotherapy in Oncology.
作者信息
Rangger Christine, Haubner Roland
机构信息
Department of Nuclear Medicine, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
出版信息
Pharmaceuticals (Basel). 2020 Jan 30;13(2):22. doi: 10.3390/ph13020022.
This review deals with the development of peptide-based radiopharmaceuticals for the use with positron emission tomography and peptide receptor radiotherapy. It discusses the pros and cons of this class of radiopharmaceuticals as well as the different labelling strategies, and summarises approaches to optimise metabolic stability. Additionally, it presents different target structures and addresses corresponding tracers, which are already used in clinical routine or are being investigated in clinical trials.
本综述涉及用于正电子发射断层扫描和肽受体放射治疗的基于肽的放射性药物的发展。它讨论了这类放射性药物的优缺点以及不同的标记策略，并总结了优化代谢稳定性的方法。此外，它介绍了不同的靶标结构并阐述了相应的示踪剂，这些示踪剂已用于临床常规或正在临床试验中进行研究。
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