酒精与痴呆症——有何关联？一项系统综述。
Alcohol and Dementia - What is the Link? A Systematic Review.
作者信息
Wiegmann Caspar, Mick Inge, Brandl Eva J, Heinz Andreas, Gutwinski Stefan
机构信息
Department of Psychiatry and Psychotherapy, Psychiatric Hospital of Charité at St. Hedwig Hospital, Berlin, Germany.
Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Berlin, Germany.
出版信息
Neuropsychiatr Dis Treat. 2020 Jan 9;16:87-99. doi: 10.2147/NDT.S198772. eCollection 2020.
BACKGROUND
Dementia is a globally increasing health issue and since no cure is currently available, prevention is crucial. The consumption of alcohol is a controversially discussed risk factor for dementia. While many previously published epidemiological studies reported a risk reduction by light to moderate alcohol consumption, there is no persuasive model of an underlying biochemical mechanism. The purpose of this article is to review current models on alcohol neurotoxicity and dementia and to analyze and compare studies focusing on the epidemiological link between alcohol consumption and the risk of dementia.
METHODS
The electronic database Pubmed was searched for studies published between 1994 and 2019 concerning the topic.
RESULTS
Available epidemiological studies are not sufficient to verify a protective effect of alcohol on dementia development.
背景
痴呆症是一个在全球范围内日益严重的健康问题，由于目前尚无治愈方法，预防至关重要。饮酒是一个备受争议的痴呆症风险因素。虽然许多先前发表的流行病学研究报告称，轻度至中度饮酒可降低风险，但目前尚无具有说服力的潜在生化机制模型。本文旨在综述当前关于酒精神经毒性与痴呆症的模型，并分析和比较关注饮酒与痴呆症风险之间流行病学联系的研究。
方法
在电子数据库PubMed中检索1994年至2019年间发表的关于该主题的研究。
结果
现有的流行病学研究不足以证实酒精对痴呆症发展具有保护作用。
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