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2013 年至 2018 年期间土耳其侵袭性感染分离株青霉素耐药性监测。

Surveillance of penicillin resistance of strains from invasive infections between 2013 and 2018 in Turkey.

机构信息

Clinics of Pediatric Infectious Diseases, SBU Izmir Tepecik Research and Training Hospital, İzmir, Turkey.

Department of Pediatric Infectious Diseases, Hacettepe University School of Medicine, Ankara, Turkey.

出版信息

J Chemother. 2020 Jul;32(4):213-216. doi: 10.1080/1120009X.2020.1721176. Epub 2020 Feb 7.

Abstract

() is regarded as the leading cause of bacterial meningitis in many regions of the world. The empiric antimicrobial treatment is mainly based on antimicrobial resistance and patient characteristics. We aimed to analyze susceptibility patterns of N. meningitidis strains isolated in Turkey. Invasive meningococci collected in a multicenter, hospital-based, epidemiological surveillance study of pediatric (0-18 years of age) bacterial meningitis cases between 2013 and 2018 were studied. Five isolates (8.7%) displayed resistance to penicillin-G, while 13 isolates (22.8%) had intermediate susceptibility. All isolates were cefotaxime and rifampin susceptible. The data shows appropriateness of third-generation cephalosporins in empirical use for meningococcal infections in children. Since Turkey is located in a transition zone geographically, surveillance reports are very crucial.

摘要

( )被认为是世界上许多地区细菌性脑膜炎的主要病因。经验性抗菌治疗主要基于抗菌药物耐药性和患者特征。我们旨在分析在土耳其分离的脑膜炎奈瑟菌菌株的药敏模式。对 2013 年至 2018 年期间在小儿(0-18 岁)细菌性脑膜炎病例的多中心、基于医院的流行病学监测研究中收集的侵袭性脑膜炎球菌进行了研究。5 株(8.7%)对青霉素 G 耐药,13 株(22.8%)中介度敏感。所有分离株均对头孢噻肟和利福平敏感。数据表明第三代头孢菌素在儿童脑膜炎奈瑟菌感染的经验性使用中是合适的。由于土耳其在地理位置上处于过渡地带,监测报告非常关键。

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