四种药物治疗方案对淋巴瘤患者姐妹染色单体交换频率的影响。
The effects of four drug regimens on sister chromatid exchange frequency in patients with lymphomas.
作者信息
Brown T, Dawson A A, Bennett B, Moore N R
机构信息
Department of Genetics and Microbiology, Foresterhill, Aberdeen, Scotland.
出版信息
Cancer Genet Cytogenet. 1988 Nov;36(1):89-102. doi: 10.1016/0165-4608(88)90078-7.
PMID:3203299
Abstract
Patients undergoing first-line chemotherapy after diagnosis of lymphoma have considerable DNA damage in their peripheral blood lymphocytes, using sister chromatid exchange (SCE) frequency as a sensitive indicator. Different drug regimens produce different patterns of changes in SCE frequency. These may be related to their potential to induce second malignancies.
摘要
以姐妹染色单体交换（SCE）频率作为敏感指标，淋巴瘤诊断后接受一线化疗的患者外周血淋巴细胞存在大量DNA损伤。不同的药物方案会使SCE频率产生不同的变化模式。这些可能与其诱发第二原发性恶性肿瘤的可能性有关。
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