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遗传性心脏疾病的心血管磁共振成像。

Cardiovascular Magnetic Resonance Imaging of Inherited Heart Conditions.

机构信息

Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Department of Cardiology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.

Kolling Institute, Royal North Shore Hospital, and Northern Clinical School, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Department of Clinical Physiology, Karolinska University Hospital, and Karolinska Institute, Stockholm, Sweden.

出版信息

Heart Lung Circ. 2020 Apr;29(4):584-593. doi: 10.1016/j.hlc.2019.12.008. Epub 2019 Dec 24.

Abstract

Imaging modalities are central to diagnosis and prognostication of confirmed or suspected inherited cardiomyopathies. The availability and use of cardiovascular magnetic resonance imaging (CMR) to supplement traditional modalities has increased substantially and has several advantages over traditional imaging techniques. CMR is unique in its ability to easily acquire images in any plane. Moreover, advances in CMR sequences have begun to enable characterisation of the myocardium without the need for invasive biopsy and has provided a major step forward in the understanding of inherited heart disease pathology and genotype-phenotype interactions. This review summarises the current role of CMR in inherited cardiomyopathies depending on their genotype and phenotype status, using arrhythmogenic right ventricular dysplasia/cardiomyopathy and hypertrophic cardiomyopathy as prototypical examples.

摘要

影像学在确诊或疑似遗传性心肌病的诊断和预后中起着核心作用。心血管磁共振成像(CMR)等补充传统影像学的方法的可用性和使用大大增加,并且具有优于传统影像学技术的多个优势。CMR 的独特之处在于能够轻松在任何平面获取图像。此外,CMR 序列的进步已经开始能够在无需进行有创性活检的情况下对心肌进行特征描述,并且在遗传性心脏病病理和基因型-表型相互作用的理解方面迈出了重要一步。本综述根据基因型和表型状态总结了 CMR 在遗传性心肌病中的当前作用,以致心律失常性右室心肌病/扩张型心肌病和肥厚型心肌病为例。

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