International Joint Laboratory of Nanofluidics and Interfaces, School of Physical Science and Technology, Northwestern Polytechnical University, 710100, Xi'an, China.
MOE Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions, School of Physical Science and Technology, Northwestern Polytechnical University, 710072, Xi'an, China.
Nat Commun. 2020 Feb 10;11(1):814. doi: 10.1038/s41467-020-14580-x.
Dimensions and surface properties are the predominant factors for the applications of nanofluidic devices. Here we use a thin liquid film as a nanochannel by inserting a gas bubble in a glass capillary, a technique we name bubble-based film nanofluidics. The height of the film nanochannel can be regulated by the Debye length and wettability, while the length independently changed by applied pressure. The film nanochannel behaves functionally identically to classical solid state nanochannels, as ion concentration polarizations. Furthermore, the film nanochannels can be used for label-free immunosensing, by principle of wettability change at the solid interface. The optimal sensitivity for the biotin-streptavidin reaction is two orders of magnitude higher than for the solid state nanochannel, suitable for a full range of electrolyte concentrations. We believe that the film nanochannel represents a class of nanofluidic devices that is of interest for fundamental studies and also can be widely applied, due to its reconfigurable dimensions, low cost, ease of fabrication and multiphase interfaces.
尺寸和表面性质是纳米流体设备应用的主要因素。在这里，我们通过在玻璃毛细管中插入气泡来将薄液膜用作纳米通道，我们将这种技术命名为基于气泡的薄膜纳流控。薄膜纳米通道的高度可以通过德拜长度和润湿性来调节，而长度则可以通过施加的压力独立改变。薄膜纳米通道的功能与经典的固态纳米通道完全相同，因为存在离子浓度极化。此外，通过在固液界面处的润湿性变化，可以将薄膜纳米通道用于无标记免疫传感。生物素-亲和素反应的最佳灵敏度比固态纳米通道高两个数量级，适用于各种电解质浓度。我们相信，薄膜纳米通道代表了一类对基础研究很有意义的纳流控装置，并且由于其可重构的尺寸、低成本、易于制造和多相界面，也可以得到广泛应用。
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