足月分娩与早产时血浆纤连蛋白的比较：一项横断面描述性分析研究。
The comparison of plasma fibronectin in term and preterm delivery: A cross-sectional, descriptive-analytical study.
作者信息
Moradi Zahra, Moradi Parvin, Hassan Meshkibaf Mohamad, Aleosfoor Mehrnoosh, Sharafi Mehdi, Jafarzadeh Saeedeh
机构信息
School of Nursing, Fasa University of Medical Sciences, Fasa, Iran.
Department of Obstetrics and Gynecology, Medical School, Fasa University of Medical Sciences, Fasa, Iran.
出版信息
Int J Reprod Biomed. 2020 Jan 27;18(1):11-20. doi: 10.18502/ijrm.v18i1.6191. eCollection 2019 Apr.
BACKGROUND
Preterm delivery is one of the main causes of infant death. Therefore, prediction of preterm delivery may eliminate a large number of prenatal complications.
OBJECTIVE
The present study aimed to understand if preterm delivery can be predicted by assessing maternal plasma fibronectin concentration.
MATERIALS AND METHODS
Serum samples from 105 pregnant women participating in this study were collected. The plasma fibronectin were measured at 24-28 wk of gestation and again at 32-36 wk of gestation. Unfortunately, only 65 of the 105 pregnant women, returned for the second sampling. The plasma fibronectin was analyzed using ELISA method and its concentration in term and preterm deliveries was compared. The delivery dates of all the women were also recorded.
RESULTS
Out of 105 pregnant women, 28 delivered preterm (26.7%). The Plasma fibronectin concentrations in women with preterm delivery were higher than in those who delivered at term (p = 0.001). Accordingly, Plasma fibronectin concentrations were significantly higher in the second serum samples (p = 0.01). Plasma fibronectin concentrations was also higher in obese women and in those suffering from preeclampsia (p = 0.12) and gestational diabetes (p = 0.81).
CONCLUSION
Plasma fibronectin concentrations test could be used as an optional screening test for preterm delivery at 28 to 34 wk of gestation in pregnant women who prefer to avoid vaginal sampling.
背景
早产是婴儿死亡的主要原因之一。因此，预测早产可能会消除大量产前并发症。
目的
本研究旨在了解通过评估孕妇血浆纤连蛋白浓度是否可以预测早产。
材料与方法
收集了参与本研究的105名孕妇的血清样本。在妊娠24 - 28周时测量血浆纤连蛋白，在妊娠32 - 36周时再次测量。遗憾的是，105名孕妇中只有65人返回进行第二次采样。使用ELISA方法分析血浆纤连蛋白，并比较其在足月分娩和早产中的浓度。还记录了所有女性的分娩日期。
结果
105名孕妇中，28人早产（26.7%）。早产女性的血浆纤连蛋白浓度高于足月分娩女性（p = 0.001）。相应地，第二次血清样本中的血浆纤连蛋白浓度显著更高（p = 0.01）。肥胖女性以及患有先兆子痫（p = 0.12）和妊娠期糖尿病（p = 0.81）的女性的血浆纤连蛋白浓度也更高。
结论
对于那些不愿接受阴道采样的孕妇，血浆纤连蛋白浓度检测可作为妊娠28至34周早产的一种可选筛查试验。
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