Departments of Psychiatry and Neurology (BR), Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania.
Department of Psychiatry and Human Behavior, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania.
J Am Geriatr Soc. 2020 May;68(5):1015-1022. doi: 10.1111/jgs.16339. Epub 2020 Feb 11.
BACKGROUND/OBJECTIVES: Improving glycemic control in older African Americans with diabetes and mild cognitive impairment (MCI) is important as the population ages and becomes more racially diverse.
Randomized controlled trial.
Recruitment from primary care practices of an urban academic medical center. Community-based treatment delivery.
Older African Americans with MCI, low medication adherence, and poor glycemic control (N = 101).
Occupational therapy (OT) behavioral intervention and diabetes self-management education.
The primary outcome was a reduction in hemoglobin A1c level of at least 0.5% at 6 months, with maintenance effects assessed at 12 months.
At 6 months, 25 of 41 (61.0%) OT participants and 22 of 46 (48.2%) diabetes self-management education participants had a reduction in hemoglobin A1c level of at least 0.5%. The model-estimated rates were 58% (95% confidence interval [CI] = 45%-75%) and 48% (95% CI = 36%-64%), respectively (relative risk [RR] = 1.21; 95% CI = 0.84-1.75; P = .31). At 12 months, the respective rates were 21 of 39 (53.8%) OT participants and 24 of 49 (49.0%) diabetes self-management education participants. The model-estimated rates were 50% (95% CI = 37%-68%) and 48% (95% CI = 36%-64%), respectively (RR = 1.05; 95% CI = 0.70-1.57; P = .81).
Both interventions improved glycemic control in older African Americans with MCI and poor glycemic control. This result reinforces the American Diabetes Association's recommendation to assess cognition in older persons with diabetes and demonstrates the potential to improve glycemic control in this high-risk population. J Am Geriatr Soc 68:1015-1022, 2020.
背景/目的:随着人口老龄化和种族多样化,改善患有糖尿病和轻度认知障碍(MCI)的老年非裔美国人的血糖控制水平非常重要。
随机对照试验。
城市学术医疗中心的基层医疗诊所招募。社区为基础的治疗实施。
患有 MCI、药物依从性差和血糖控制不佳的老年非裔美国人(N=101)。
职业治疗(OT)行为干预和糖尿病自我管理教育。
主要结局是 6 个月时血红蛋白 A1c 水平至少降低 0.5%,并在 12 个月时评估维持效果。
在 6 个月时,41 名 OT 参与者中的 25 名(61.0%)和 46 名糖尿病自我管理教育参与者中的 22 名(48.2%)血红蛋白 A1c 水平至少降低了 0.5%。模型估计的比率分别为 58%(95%置信区间[CI] = 45%-75%)和 48%(95% CI = 36%-64%)(相对风险[RR] = 1.21;95% CI = 0.84-1.75;P = 0.31)。在 12 个月时,OT 参与者分别为 39 名中的 21 名(53.8%)和糖尿病自我管理教育参与者中的 49 名中的 24 名(49.0%)。模型估计的比率分别为 50%(95% CI = 37%-68%)和 48%(95% CI = 36%-64%)(RR = 1.05;95% CI = 0.70-1.57;P = 0.81)。
这两种干预措施都改善了患有 MCI 和血糖控制不佳的老年非裔美国人的血糖控制。这一结果强化了美国糖尿病协会的建议,即在糖尿病患者中评估认知功能,并证明了在这一高风险人群中改善血糖控制的潜力。J Am Geriatr Soc 68:1015-1022, 2020.