铜催化的亚砜叶立德的环化或同偶联：2,3-二芳基喹啉或α,α,β-三羰基亚砜叶立德的合成。
Copper-Catalyzed Annulation or Homocoupling of Sulfoxonium Ylides: Synthesis of 2,3-Diaroylquinolines or α,α,β-Tricarbonyl Sulfoxonium Ylides.
机构信息
Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Pharmaceutical Sciences , Jiangnan University . Lihu Avenue 1800 , Wuxi 214122 , Jiangsu Province , P.R. China.
School of Chemical and Material Engineering , Jiangnan University , Wuxi 214122 , Jiangsu Province , P.R. China.
出版信息
Org Lett. 2020 Feb 21;22(4):1504-1509. doi: 10.1021/acs.orglett.0c00085. Epub 2020 Feb 11.
An unprecedented copper-catalyzed reaction of sulfoxonium ylides and anthranils is reported that enables an easy access to 2,3-diaroylquinolines through a [4+1+1] annulation. Copper-catalyzed homocoupling of sulfoxonium ylides provided α,α,β-tricarbonyl sulfoxonium ylides, which provides a strategy to extend the carbon chain through C-C bond formation. The utility of the products as well as the mechanistic details of the process are presented.
本文报道了一种前所未有的亚砜叶立德和邻苯二甲酰亚胺的铜催化反应，通过[4+1+1]环化反应，可轻松构建 2,3-二芳基喹啉。亚砜叶立德的铜催化同偶联提供了α,α,β-三羰基亚砜叶立德，为通过 C-C 键形成扩展碳链提供了一种策略。展示了产物的实用性以及该过程的机理细节。
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