法医尸检队列中的肺结核：沙特阿拉伯的一项初步研究。
Pulmonary tuberculosis in a cohort of forensic autopsies: a preliminary study from Saudi Arabia.
作者信息
Madadin Mohammed, Menezes Ritesh G, Al Tamimi Dalal M, Kharoshah Magdy A, Al Hamad Mohammad, Al-Nasser Mona, Al Madani Osama M
机构信息
Department of Pathology, College of Medicine, King Fahd Hospital of the University, Imam Abulrahman Bin Faisal University, Dammam, Saudi Arabia.
Forensic Medicine Centre, Dammam, Saudi Arabia.
出版信息
J Int Med Res. 2020 Feb;48(2):300060519896434. doi: 10.1177/0300060519896434.
AIMS
The purpose of this study was to identify any cases of previously undiagnosed pulmonary tuberculosis during autopsy.
METHODS
This prospective study investigated a cohort of deceased individuals that underwent a full external and internal postmortem examination at the Forensic Medicine Centre, Dammam, Saudi Arabia. Gross pathology, histopathology and molecular pathology were used to identify pulmonary tuberculosis in forensic autopsy samples from the lungs.
RESULTS
A total of 82 cases autopsied were included in the study. The mean ± SD age of the study cohort was 35.5 ± 10.3 years (range, 20–80 years). Males ( = 70; 85.37%) outnumbered females. The deceased were from 15 different countries. The number of Saudis was 16 (19.51%). The maximum number of non-Saudis was from India with 26 cases (31.71%). There were no cases of undiagnosed pulmonary tuberculosis detected for the first time at autopsy.
CONCLUSIONS
Although the prevalence of pulmonary tuberculosis in forensic autopsy cases in this preliminary study was nil, we recommend further studies to be conducted on a larger scale and in different autopsy centres throughout Saudi Arabia to get an insight into the burden of clinically undiagnosed tuberculosis in the entire country.
目的
本研究的目的是在尸检过程中识别出任何先前未被诊断出的肺结核病例。
方法
这项前瞻性研究调查了一组在沙特阿拉伯达曼法医学中心接受全面尸体外部和内部检查的死者。大体病理学、组织病理学和分子病理学被用于在来自肺部的法医尸检样本中识别肺结核。
结果
本研究共纳入82例尸检病例。研究队列的平均年龄±标准差为35.5±10.3岁（范围为20 - 80岁）。男性（n = 70；85.37%）多于女性。死者来自15个不同国家。沙特人有16例（19.51%）。非沙特人数量最多的是印度，有26例（31.71%）。在尸检时未首次检测到未被诊断出的肺结核病例。
结论
尽管在这项初步研究中法医尸检病例中肺结核的患病率为零，但我们建议在沙特阿拉伯各地更大规模地以及在不同的尸检中心进行进一步研究，以深入了解全国临床未诊断出的结核病负担。
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