快速表型分析助力疟疾个体化药物治疗。
Rapid phenotyping towards personalized malaria medicine.
机构信息
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.
出版信息
Malar J. 2020 Feb 11;19(1):68. doi: 10.1186/s12936-020-3149-4.
Abstract
Malaria is major public health concerns which continues to claim the lives of more than 435,000 people each year. The challenges with anti-malarial drug resistance and detection of low parasitaemia forms an immediate barrier to achieve the fast-approaching United Nations Sustainable Development Goals of ending malaria epidemics by 2030. In this Opinion article, focusing on the recent published technologies, in particularly the nuclear magnetic resonance (NMR)-based diagnostic technologies, the authors offer their perspectives and highlight ways to bring these point-of-care technologies towards personalized medicine. To this end, they advocate an open sourcing initiative to rapidly close the gap between technological innovations and field implementation.
摘要
疟疾是一个重大的公共卫生关注点，每年仍有超过 43.5 万人因此失去生命。抗疟药物耐药性的挑战以及对低寄生虫血症形式的检测，立即构成了实现联合国 2030 年消除疟疾流行的可持续发展目标的障碍。在这篇观点文章中，作者重点关注了最近发表的技术，特别是基于核磁共振（NMR）的诊断技术，提出了他们的观点，并强调了将这些即时检测技术推向个性化医疗的方法。为此，他们主张采取开源倡议，以迅速缩小技术创新与现场实施之间的差距。
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