唾液胎盘生长因子水平改变与子痫前期有关。
Altered level of salivary placental growth factor is associated with preeclampsia.
机构信息
School of Dentistry, University of California Los Angeles, United States.
Mother Infant Research Institute, Tufts Medical Center, United States.
出版信息
Placenta. 2020 Jan 15;90:118-120. doi: 10.1016/j.placenta.2019.12.016. Epub 2019 Dec 23.
Abstract
A pilot, case-control study was conducted to compare the concentrations of placental growth factor (PlGF) and placental alkaline phosphatase (PLAP) in saliva of preeclampsia (PE) patients with normotensive controls in the second and third trimesters. Measured by ELISA assays, levels of salivary PlGF were significantly lower in PE patients (n = 13) compared to controls (n = 15) (two-way ANOVA, p = 0.0208) independent of gestational age at time of collection (p = 0.49). Salivary PLAP differences between PE and controls were not statistically significant. Placenta-specific proteins are detectable in maternal saliva and may serve as noninvasive biomarkers to monitor placenta health and disease during pregnancy.
摘要
一项旨在比较第二和第三孕期先兆子痫（PE）患者和正常血压对照组唾液中胎盘生长因子（PlGF）和胎盘碱性磷酸酶（PLAP）浓度的初步病例对照研究。通过 ELISA 检测，PE 患者（n=13）唾液中 PlGF 水平明显低于对照组（n=15）（双因素方差分析，p=0.0208），与采集时的妊娠年龄无关（p=0.49）。PE 和对照组唾液中 PLAP 的差异无统计学意义。胎盘特异性蛋白可在母体唾液中检测到，可能作为非侵入性生物标志物，用于监测孕期胎盘健康和疾病。
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