[减毒活流感疫苗对儿童季节性流感有效性的荟萃分析]
[Meta-analysis on effectiveness of live attenuated influenza vaccine against seasonal influenza in children].
作者信息
Tao Y Y, Jin P F, Zhu F C
机构信息
School of Public Health, Southeast University, Nanjing 210009, China.
Department of Vaccine Clinical Evaluation, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
出版信息
Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Jan 10;41(1):103-110. doi: 10.3760/cma.j.issn.0254-6450.2020.01.019.
To evaluate the effectiveness of live attenuated influenza vaccine (LAIV) in the prevention of seasonal influenza in children aged 2-17 years. Literature retrieval of case-control studies on the effectiveness of LAIV against seasonal influenza in children published from January 2003 to November 2018 was conducted through Web of Science, PubMed, and ScienceDirect databases. The Stata 13.1 software was used for Meta-analysis. A total of 14 studies were included in this study, and all were test-negative design (TND) studies. Our Meta-analysis showed that the effectiveness of LAIV in children was 49 (95: 40-57). Subgroup analysis found that the protection rate of LAIV was 35 against influenza A (H1N1) pdm09 (95: 5-56), 35 against influenza A (H3N2) (95: 21-46), and 71 against influenza B (95: 55-82). The protection rates of trivalent LAIV and quadrivalent LAIV in children were 56 (95: 48-63) and 44 (95: 27-57), respectively. The protection rates of LAIV in Europe and North America were 65 (95: 47-77) and 46 (95: 36-55), respectively. LAIV has a certain preventive effect on seasonal influenza in children aged 2-17 years.
评估减毒活流感疫苗（LAIV）在预防2至17岁儿童季节性流感方面的有效性。通过Web of Science、PubMed和ScienceDirect数据库，对2003年1月至2018年11月发表的关于LAIV预防儿童季节性流感有效性的病例对照研究进行文献检索。使用Stata 13.1软件进行Meta分析。本研究共纳入14项研究，均为检验阴性设计（TND）研究。我们的Meta分析表明，LAIV对儿童的有效性为49（95%置信区间：40 - 57）。亚组分析发现，LAIV对甲型（H1N1）pdm09流感的保护率为35（95%置信区间：5 - 56），对甲型（H3N2）流感的保护率为35（95%置信区间：21 - 46），对乙型流感的保护率为71（95%置信区间：55 - 82）。三价LAIV和四价LAIV对儿童的保护率分别为56（95%置信区间：48 - 63）和44（95%置信区间：27 - 57）。LAIV在欧洲和北美的保护率分别为65（95%置信区间：47 - 77）和46（95%置信区间：36 - 55）。LAIV对2至17岁儿童的季节性流感有一定预防作用。
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