对三阴性乳腺癌的分层因素进行分层。 - Suppr

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Stratifying the stratifiers of triple negative breast cancer.

作者信息

Wang Dong-Yu, Jiang Zhe, Zacksenhaus Eldad

出版信息

Oncotarget. 2020 Jan 28;11(4):306-308. doi: 10.18632/oncotarget.27455.

DOI:10.18632/oncotarget.27455

PMID:32064036

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6996905/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91b5/6996905/5a851a55af68/oncotarget-11-306-g001.jpg

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A subgroup of microRNAs defines PTEN-deficient, triple-negative breast cancer patients with poorest prognosis and alterations in RB1, MYC, and Wnt signaling.一小群 microRNAs 定义了 PTEN 缺失、三阴性乳腺癌患者，这些患者的预后最差，并且存在 RB1、MYC 和 Wnt 信号通路的改变。

Breast Cancer Res. 2019 Jan 31;21(1):18. doi: 10.1186/s13058-019-1098-z.

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer.阿替利珠单抗联合白蛋白紫杉醇治疗晚期三阴性乳腺癌。

N Engl J Med. 2018 Nov 29;379(22):2108-2121. doi: 10.1056/NEJMoa1809615. Epub 2018 Oct 20.

microRNA-143/145 loss induces Ras signaling to promote aggressive Pten-deficient basal-like breast cancer.微小RNA-143/145缺失诱导Ras信号传导，促进侵袭性PTEN缺失的基底样乳腺癌。

JCI Insight. 2017 Aug 3;2(15). doi: 10.1172/jci.insight.93313.

RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation.三阴性乳腺癌中的RB1缺陷会诱导线粒体蛋白质翻译。

J Clin Invest. 2016 Oct 3;126(10):3739-3757. doi: 10.1172/JCI81568. Epub 2016 Aug 29.

Common and distinct features of mammary tumors driven by Pten-deletion or activating Pik3ca mutation.由Pten缺失或激活型Pik3ca突变驱动的乳腺肿瘤的共同特征和独特特征。

Oncotarget. 2016 Feb 23;7(8):9060-8. doi: 10.18632/oncotarget.6985.

Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K.乳腺上皮中Pten和p53的联合缺失会加速依赖eEF2K的三阴性乳腺癌的发展。

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Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies.鉴定人类三阴性乳腺癌亚型和临床前模型以选择靶向治疗药物。

J Clin Invest. 2011 Jul;121(7):2750-67. doi: 10.1172/JCI45014.

Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status.Rb 缺失在小鼠乳腺祖细胞中诱导管腔-B 或基底样/EMT 肿瘤亚型，这取决于 p53 状态。

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