Yovich J L, Matson P L
PIVET Medical Centre, Perth, Western Australia.
Br J Obstet Gynaecol. 1988 Nov;95(11):1120-7. doi: 10.1111/j.1471-0528.1988.tb06789.x.
The outcome of 1034 pregnancies in women who conceived after referral for infertility management in seven treatment groups is detailed. The mean early pregnancy wastage (before 20 weeks gestation) was 27% and ranged from 18% after AID (artificial insemination by donor semen) to 33% after IVF-ET (in-vitro fertilization and embryo transfer). These differences were not due to maternal age which was similar in all groups (means between 29.7 and 32.7 years). Excluding the AID group, there was a high rate of ectopic pregnancy which was significantly higher after GIFT (gamete intrafallopian transfer) and was only partly related to underlying tubal disease. Blighted ova was the main category of early pregnancy loss and was highest after AIH (artificial insemination by husband's semen). There was a higher rate of biochemical pregnancies after GIFT, PROST (pronuclear stage tubal transfer) and IVF-ET. Our findings confirm a high pregnancy wastage rate in subfertile women and highlight deficiencies in the sperm separation, gamete handling and IVF/embryo culture techniques.
详细介绍了七个治疗组中因不孕不育转诊后受孕的1034名女性的妊娠结局。早期妊娠流产（妊娠20周前）的平均发生率为27%，范围从供精人工授精（AID）后的18%到体外受精与胚胎移植（IVF-ET）后的33%。这些差异并非由于所有组中相似的产妇年龄（均值在29.7至32.7岁之间）。排除AID组后，宫外孕发生率较高，在配子输卵管内移植（GIFT）后显著更高，且仅部分与潜在的输卵管疾病相关。枯萎卵是早期妊娠丢失的主要类型，在夫精人工授精（AIH）后发生率最高。在GIFT、原核期输卵管内移植（PROST）和IVF-ET后，生化妊娠发生率较高。我们的研究结果证实了亚生育女性中较高的妊娠流产率，并突出了精子分离、配子处理及IVF/胚胎培养技术中的不足之处。
