Teichmann-Knorrn Svenja, Doerfelt Stefanie, Doerfelt René
Department for Clinical Veterinary Medicine, Clinic of Small Animal Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.
J Vet Emerg Crit Care (San Antonio). 2020 Mar;30(2):194-201. doi: 10.1111/vec.12934. Epub 2020 Feb 20.
To evaluate dogs treated with hemodialysis for severe metaldehyde intoxication and to compare them with conventionally-managed patients.
Retrospective study (2012-2017).
University teaching hospital.
Data from 18 dogs with severe metaldehyde intoxication were analyzed. Eleven dogs were treated with intermittent hemodialysis and 7 managed conventionally.
None.
Metaldehyde poisoning was diagnosed based on clinical signs and toxicological analysis or presence of turquoise material in the gastrointestinal content. Clinical signs, additional treatments, dialysis prescription, duration of anesthesia and hospitalization, complications, and outcome were documented. Results were analyzed by t-test, Mann-Whitney U-test, and Chi-square test. P < 0.05 was considered significant. Dialysis was performed for median (range) 180 min (150-420 min) with median of 2.28 L/kg (1.66-4.48 L/kg) blood volume processed. In the hemodialysis group, anesthesia was discontinued at a median of 3.0 hours (1.5-6.7 h) after starting dialysis. The conventional-group received general anesthesia for a median of 17.5 hours (7.0-30.5 h). No further anticonvulsive treatment was necessary for the hemodialysis group. Time to hospital discharge was shorter in dialyzed dogs (median 18 h; 15-41 h) compared to conventionally treated dogs (median 89 h; 61-168 h; P = 0.0014). Aspiration pneumonia was reported in 5 conventionally treated dogs and none of the dialyzed dogs (P = 0.001). Five dialyzed dogs developed hematoma at the dialysis catheter site. One dog in each group was euthanized.
Hemodialysis significantly decreases the requirement for anesthesia and length of hospitalization in dogs with metaldehyde intoxication. Aspiration pneumonia occurred less often in dialyzed patients. Prospective studies are warranted to confirm the clinical utility of hemodialysis in dogs with metaldehyde poisoning.
评估接受血液透析治疗的严重聚乙醛中毒犬，并将其与传统治疗的犬进行比较。
回顾性研究（2012 - 2017年）。
大学教学医院。
分析18只严重聚乙醛中毒犬的数据。11只犬接受间歇性血液透析治疗，7只犬接受传统治疗。
无。
根据临床症状、毒理学分析或胃肠道内容物中绿松石样物质的存在诊断聚乙醛中毒。记录临床症状、额外治疗、透析处方、麻醉和住院时间、并发症及结局。结果采用t检验、曼 - 惠特尼U检验和卡方检验进行分析。P < 0.05被认为具有统计学意义。透析中位时间（范围）为180分钟（150 - 420分钟），处理的血容量中位数为2.28 L/kg（1.66 - 4.48 L/kg）。在血液透析组，透析开始后中位3.0小时（1.5 - 6.7小时）停止麻醉。传统治疗组接受全身麻醉的中位时间为17.5小时（7.0 - 30.5小时）。血液透析组无需进一步抗惊厥治疗。与传统治疗的犬（中位89小时；61 - 168小时；P = 0.0014）相比，接受透析的犬出院时间更短（中位18小时；15 - 41小时）。5只接受传统治疗的犬发生吸入性肺炎，而接受透析的犬无一发生（P = 0.001）。5只接受透析的犬在透析导管部位出现血肿。每组各有1只犬实施安乐死。
血液透析显著降低聚乙醛中毒犬的麻醉需求和住院时间。透析患者发生吸入性肺炎的频率较低。有必要进行前瞻性研究以证实血液透析在聚乙醛中毒犬中的临床应用价值。
