胎盘屏障与自闭症谱系障碍：催乳素和多巴胺在胎儿大脑发育中的作用 - 第二部分
Placental Barrier and Autism Spectrum Disorders: The Roles of Prolactin and Dopamine in the Developing Fetal Brain-Part II.
作者信息
Yarlagadda Atmaram, Acharya Ganesh, Kasaraneni Jayaprada, Hampe Christiane S, Clayton Anita H
机构信息
Dr. Yarlagadda is with the Department of Defense and the University of Virginia in Charlottesville, Virginia.
Dr. Acharya is with the Karolinska Institutet in Solna, Sweden.
出版信息
Innov Clin Neurosci. 2019 Nov 1;16(11-12):36-39.
The inverse relationship between prolactin and dopamine is important in the context of treatment with antipsychotic medications in men and nonpregnant women with thought disorders. Likewise, increased levels of prolactin as confirmation of recent seizure and the reciprocal levels of prolactin and dopamine in both eclampsia (seizures) and pre-eclampsia might have significant potential effects on a growing fetus. In this article, we attempt to outline the influence of these associations on autism spectrum disorders (ASDs) in children born to mothers with established diagnoses of eclampsia and/or pre-eclampsia. Our previously published paper, "Placental Barrier and Autism Spectrum Disorders: The Role of Prolactin and Dopamine on the Developing Fetal Brain," summarized evidence for dysregulated dopamine and prolactin levels in the etiology of ASDs and suggested a possible method for assessing whether such aberrations increase the risk of ASDs. The present paper as Part 2 expands on the published data that support this theory and proposes a study design to corroborate this hypothesis.
在患有思维障碍的男性和未怀孕女性中，使用抗精神病药物治疗时，催乳素与多巴胺之间的反向关系很重要。同样，催乳素水平升高作为近期癫痫发作的证据，以及子痫（癫痫发作）和先兆子痫中催乳素与多巴胺的相互关系水平，可能对发育中的胎儿有重大潜在影响。在本文中，我们试图概述这些关联对患有子痫和/或先兆子痫确诊的母亲所生儿童自闭症谱系障碍（ASD）的影响。我们之前发表的论文《胎盘屏障与自闭症谱系障碍：催乳素和多巴胺对发育中胎儿大脑的作用》总结了ASD病因中多巴胺和催乳素水平失调的证据，并提出了一种评估此类异常是否会增加ASD风险的可能方法。作为第2部分的本文扩展了支持该理论的已发表数据，并提出了一项研究设计来证实这一假设。
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