制定并临床评估标准化荔枝提取物治疗皮肤色素沉着和衰老的制剂。

Formulation and clinical evaluation of the standardized Litchi chinensis extract for skin hyperpigmentation and aging treatments.

机构信息

School of Cosmetic Science, Mae-Fah-Luang University, 57100 Chiang-Rai, Thailand; Phytocosmetics and Cosmeceuticals Research Group, Mae-Fah-Luang University, 57100 Chiang-Rai, Thailand.

出版信息

Ann Pharm Fr. 2020 Mar;78(2):142-149. doi: 10.1016/j.pharma.2020.01.004. Epub 2020 Jan 23.

DOI:10.1016/j.pharma.2020.01.004

PMID:32089252

Abstract

INTRODUCTION

The standardized litchi extract had been revealed on phytochemical actives, in vitro and cellular activities against aging and darkening of skin. However, a formulation containing the extract has never been developed as per clinical evaluated.

MATERIALS AND METHODS

The litchi serum was developed, safety and efficacy were clinically evaluated in human volunteers. The stable and none irritated 0.05 and 0.1% litchi serums were randomized-single blind placebo control clinical applied on the inner forearm of 29 volunteers for a consecutive 112 days and monitored by Mexameter® MX18, Cutometer® MPA 580 and Visioscan® VC 98.

RESULTS

Skin lightening efficacy of the 0.1% and 0.05% litchi serum was significantly (P<0.001 and P<0.05) higher than the placebo. Skin elasticity and wrinkle reduction was significantly (P<0.05 and P<0.005) achieved by the 0.1% litchi serum. The efficacy of litchi serums was confirmed by a split-face, randomized, single-blind controlled that the 0.1% litchi serum was significantly (P<0.05) better than the 0.05% one of all examined parameters.

CONCLUSION

Safety and efficacy of litchi extract are clinically confirmed for hyperpigmentation and aging of skin treatments.

摘要

简介

标准化荔枝提取物已被证明具有植物化学活性，具有体外和细胞活性，可对抗皮肤衰老和变黑。然而，从未根据临床评估开发过含有该提取物的配方。

材料和方法

开发了荔枝血清，并在人体志愿者中进行了安全性和功效的临床评估。稳定且无刺激性的 0.05%和 0.1%荔枝血清随机单盲安慰剂对照临床应用于 29 名志愿者的前臂内侧，连续 112 天，并通过 Mexameter® MX18、Cutometer® MPA 580 和 Visioscan® VC 98 进行监测。

结果

0.1%和 0.05%荔枝血清的皮肤美白功效明显（P<0.001 和 P<0.05）优于安慰剂。0.1%荔枝血清可显著（P<0.05 和 P<0.005）增加皮肤弹性和减少皱纹。一项分割面部、随机、单盲对照研究证实了荔枝血清的功效，0.1%荔枝血清在所有检查参数方面均明显（P<0.05）优于 0.05%荔枝血清。