评估 SARS-CoV-2 感染患者的泪液和结膜分泌物中的冠状病毒。
Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection.
机构信息
Department of Ophthalmology, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China.
出版信息
J Med Virol. 2020 Jun;92(6):589-594. doi: 10.1002/jmv.25725. Epub 2020 Mar 12.
OBJECTIVE
This study aimed to assess the presence of novel coronavirus in tears and conjunctival secretions of SARS-CoV-2-infected patients.
METHODS
A prospective interventional case series study was performed, and 30 confirmed novel coronavirus pneumonia (NCP) patients were selected at the First Affiliated Hospital of Zhejiang University from 26 January 2020 to 9 February 2020. At an interval of 2 to 3 days, tear and conjunctival secretions were collected twice with disposable sampling swabs for reverse-transcription polymerase chain reaction (RT-PCR) assay.
RESULTS
Twenty-one common-type and nine severe-type NCP patients were enrolled. Two samples of tear and conjunctival secretions were obtained from the only one patient with conjunctivitis yielded positive RT-PCR results. Fifty-eight samples from other patents were all negative.
CONCLUSION
We speculate that SARS-CoV-2 may be detected in the tears and conjunctival secretions in NCP patients with conjunctivitis.
目的
本研究旨在评估新型冠状病毒在 SARS-CoV-2 感染患者的泪液和结膜分泌物中的存在情况。
方法
进行了一项前瞻性干预性病例系列研究，2020 年 1 月 26 日至 2 月 9 日期间，在浙江大学第一附属医院选择了 30 例确诊的新型冠状病毒肺炎（NCP）患者。每隔 2 到 3 天，使用一次性采样拭子采集两次泪液和结膜分泌物，进行逆转录聚合酶链反应（RT-PCR）检测。
结果
共纳入 21 例普通型和 9 例重型 NCP 患者。唯一 1 例结膜炎患者的 2 份泪液和结膜分泌物样本 RT-PCR 检测结果为阳性。其他 58 例患者的样本均为阴性。
结论
我们推测 SARS-CoV-2 可能存在于患有结膜炎的 NCP 患者的泪液和结膜分泌物中。
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