人乳头瘤病毒阳性非口咽鳞状细胞癌的危险因素
Risk factors for human papillomavirus-positive nonoropharyngeal squamous cell carcinoma.
作者信息
Windon Melina J, D'Souza Gypsyamber, Waterboer Tim, Rooper Lisa, Westra William H, Troy Tanya, Pardoll Drew, Tan Marietta, Yavvari Siddhartha, Kiess Ana P, Miles Brett, Mydlarz Wojciech K, Ha Patrick K, Bender Noemi, Eisele David W, Fakhry Carole
机构信息
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
出版信息
Head Neck. 2020 Aug;42(8):1954-1962. doi: 10.1002/hed.26116. Epub 2020 Feb 26.
BACKGROUND
Human papillomavirus (HPV)-positive oropharyngeal cancer (HPV-OPC) is distinct from HPV-unassociated head and neck cancer. However, whether risk factors for HPV-positive oropharyngeal and nonoropharyngeal squamous cell cancer are the same is unclear.
METHODS
Incident cases of HPV-positive head and neck cell cancer and matched non-cancer controls were enrolled in a multi-institutional, prospective study examining risk factors, biomarkers, and survival.
RESULTS
HPV-nonOPC (n = 20) were more likely to be ever smokers than controls (n = 80, OR 3.49, 95%CI 1.11-10.9) and HPV-OPC (n = 185, OR 3.28, 95%CI 1.10-10.2). Compared with HPV-OPC, HPV-nonOPC were less likely to have had over 3 oral sexual partners (OR 0.29, 95%CI 0.06-0.9), more likely to have multimorbidity (OR 3.30, 95%CI 1.04-10.5), and less likely to have antibodies to HPV16 E6 (90% vs 28%, OR 0.05, 95%CI 0.02-0.2). HPV-nonOPC had worse 4-year OS (77% vs 96%, P = .001) and RFS (69% vs 94%, P < .001) than HPV-OPC.
CONCLUSIONS
HPV-positive nonoropharyngeal are distinct from HPV-positive oropharyngeal cancers.
背景
人乳头瘤病毒（HPV）阳性的口咽癌（HPV-OPC）与HPV阴性的头颈癌不同。然而，HPV阳性的口咽和非口咽鳞状细胞癌的危险因素是否相同尚不清楚。
方法
HPV阳性头颈细胞癌的发病病例和匹配的非癌对照纳入一项多机构前瞻性研究，该研究考察危险因素、生物标志物和生存率。
结果
HPV非口咽癌（n = 20）曾经吸烟者比对照（n = 80，比值比3.49，95%可信区间1.11 - 10.9）和HPV口咽癌（n = 185，比值比3.28，95%可信区间1.10 - 10.2）更常见。与HPV口咽癌相比，HPV非口咽癌有超过3个口交性伴侣的可能性较小（比值比0.29，95%可信区间0.06 - 0.9），有多种疾病的可能性较大（比值比3.30，95%可信区间1.04 - 10.5），且有HPV16 E6抗体的可能性较小（90%对28%，比值比0.05，95%可信区间0.02 - 0.2）。HPV非口咽癌的4年总生存率（77%对96%，P = 0.001）和无复发生存率（69%对94%，P < 0.001）比HPV口咽癌差。
结论
HPV阳性的非口咽癌与HPV阳性的口咽癌不同。
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