Boler Anup K, Akhtar Sana, Bandyopadhyay Arghya, Roy Shreosee
Department of Pathology, Burdwan Medical College and Hospital, Burdwan, West Bengal, India.
Indian J Pathol Microbiol. 2020 Feb;63(Supplement):S91-S93. doi: 10.4103/IJPM.IJPM_23_19.
Dedifferentiated endometrioid carcinoma or dedifferentiated endometrioid adenocarcinoma (DEAC) is defined by the presence of undifferentiated carcinoma with endometrioid carcinoma. Undifferentiated component can be misinterpreted as solid component of high-grade endometrioid carcinoma or sarcomatous component of malignant mixed mullerian tumor. We present two cases of DEAC. Two postmenopausal women underwent hysterectomy for vaginal bleeding. Microscopically, sections from the endometrial tumors showed a biphasic growth consisting of an undifferentiated component and a glandular component with sharp transition between the two components. The undifferentiated component showed focal positivity for cytokeratin and vimentin, while glandular component was diffusely positive for cytokeratin and negative for vimentin expression.
去分化子宫内膜样癌或去分化子宫内膜样腺癌（DEAC）的定义是存在未分化癌与子宫内膜样癌。未分化成分可能被误诊为高级别子宫内膜样癌的实性成分或恶性混合苗勒管肿瘤的肉瘤成分。我们报告两例DEAC。两名绝经后女性因阴道出血接受了子宫切除术。显微镜下，子宫内膜肿瘤切片显示为双相生长，由未分化成分和腺性成分组成，两者之间有明显的过渡。未分化成分对细胞角蛋白和波形蛋白呈局灶性阳性，而腺性成分对细胞角蛋白呈弥漫性阳性，对波形蛋白表达呈阴性。
