PTBP1 在可变剪接、糖酵解和致癌作用中的作用。
Roles of PTBP1 in alternative splicing, glycolysis, and oncogensis.
机构信息
NHC Key Laboratory of Carcinogenesis (Central South University) and the Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China.
出版信息
J Zhejiang Univ Sci B. 2020;21(2):122-136. doi: 10.1631/jzus.B1900422. Epub 2020 Feb 5.
Polypyrimidine tract-binding protein 1 (PTBP1) plays an essential role in splicing and is expressed in almost all cell types in humans, unlike the other proteins of the PTBP family. PTBP1 mediates several cellular processes in certain types of cells, including the growth and differentiation of neuronal cells and activation of immune cells. Its function is regulated by various molecules, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and RNA-binding proteins. PTBP1 plays roles in various diseases, particularly in some cancers, including colorectal cancer, renal cell cancer, breast cancer, and glioma. In cancers, it acts mainly as a regulator of glycolysis, apoptosis, proliferation, tumorigenesis, invasion, and migration. The role of PTBP1 in cancer has become a popular research topic in recent years, and this research has contributed greatly to the formulation of a useful therapeutic strategy for cancer. In this review, we summarize recent findings related to PTBP1 and discuss how it regulates the development of cancer cells.
多嘧啶 tract 结合蛋白 1（PTBP1）在剪接中发挥着重要作用，几乎在人类所有细胞类型中都有表达，这与 PTBP 家族的其他蛋白不同。PTBP1 在某些类型的细胞中介导多种细胞过程，包括神经元细胞的生长和分化以及免疫细胞的激活。其功能受多种分子的调节，包括 microRNAs（miRNAs）、长非编码 RNA（lncRNA）和 RNA 结合蛋白。PTBP1 在各种疾病中发挥作用，特别是在某些癌症中，包括结直肠癌、肾细胞癌、乳腺癌和神经胶质瘤。在癌症中，它主要作为糖酵解、细胞凋亡、增殖、肿瘤发生、侵袭和迁移的调节剂发挥作用。PTBP1 在癌症中的作用已成为近年来的热门研究课题，这一研究对制定癌症的有效治疗策略做出了巨大贡献。在这篇综述中，我们总结了与 PTBP1 相关的最新发现，并讨论了它如何调节癌细胞的发展。
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