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骨盆环损伤中的主动脉球囊阻断术(REBOA):ABO创伤登记处的初步结果

Aortic balloon occlusion (REBOA) in pelvic ring injuries: preliminary results of the ABO Trauma Registry.

作者信息

Coccolini Federico, Ceresoli Marco, McGreevy David T, Sadeghi Mitra, Pirouzram Artai, Toivola Asko, Skoog Per, Idoguchi Koji, Kon Yuri, Ishida Tokiya, Matsumura Yosuke, Matsumoto Junichi, Reva Viktor, Maszkowski Mariusz, Fugazzola Paola, Tomasoni Matteo, Cicuttin Enrico, Ansaloni Luca, Zaghi Claudia, Sibilla Maria Grazia, Cremonini Camilla, Bersztel Adam, Caragounis Eva-Corina, Falkenberg Mårten, Handolin Lauri, Oosthuizen George, Szarka Endre, Manchev Vassil, Wannatoop Tongporn, Chang Sung Wook, Kessel Boris, Hebron Dan, Shaked Gad, Bala Miklosh, Ordoñez Carlos A, Hibert-Carius Peter, Chiarugi Massimo, Nilsson Kristofer F, Larzon Thomas, Gamberini Emiliano, Agnoletti Vanni, Catena Fausto, Hörer Tal M

机构信息

General, Emergency and Trauma Surgery Department, Pisa University Hospital, Via Paradisa 2, 56124, Pisa, Italy.

General, Emergency and Trauma Surgery Department, Bufalini Hospital, Cesena, Italy.

出版信息

Updates Surg. 2020 Jun;72(2):527-536. doi: 10.1007/s13304-020-00735-4. Epub 2020 Mar 4.

Abstract

EndoVascular and Hybrid Trauma Management (EVTM) has been recently introduced in the treatment of severe pelvic ring injuries. This multimodal method of hemorrhage management counts on several strategies such as the REBOA (resuscitative endovascular balloon occlusion of the aorta). Few data exist on the use of REBOA in patients with a severely injured pelvic ring. The ABO (aortic balloon occlusion) Trauma Registry is designed to capture data for all trauma patients in hemorrhagic shock where management includes REBOA placement. Among all patients included in the ABO registry, 72 patients presented with severe pelvic injuries and were the population under exam. 66.7% were male. Mean and median ISS were respectively 43 and 41 (SD ± 13). Isolated pelvic injuries were observed in 12 patients (16.7%). Blunt trauma occurred in 68 patients (94.4%), penetrating in 2 (2.8%) and combined in 2 (2.8%). Type of injury: fall from height in 15 patients (23.1%), traffic accident in 49 patients (75.4%), and unspecified impact in 1 patient (1.5%). Femoral access was gained pre-hospital in 1 patient, in emergency room in 43, in operating room in 12 and in angio-suite in 16. REBOA was positioned in zone 1 in 59 patients (81,9%), in zone 2 in 1 (1,4%) and in zone 3 in 12 (16,7%). Aortic occlusion was partial/periodical in 35 patients (48,6%) and total occlusion in 37 patients (51,4%). REBOA associated morbidity rate: 11.1%. Overall mortality rate was 54.2% and early mortality rate (≤ 24 h) was 44.4%. In the univariate analysis, factors related to early mortality (≤ 24 h) are lower pH values (p = 0.03), higher base deficit (p = 0.021), longer INR (p = 0.012), minor increase in systolic blood pressure after the REBOA inflation (p = 0.03) and total aortic occlusion (p = 0.008). None of these values resulted significant in the multivariate analysis. In severe hemodynamically unstable pelvic trauma management, REBOA is a viable option when utilized in experienced centers as a bridge to other treatments; its use might be, however, accompanied with severe-to-lethal complications.

摘要

血管内及混合创伤管理(EVTM)最近已被引入严重骨盆环损伤的治疗中。这种多模式出血管理方法依靠多种策略,如主动脉内球囊阻断复苏术(REBOA)。关于在严重骨盆环损伤患者中使用REBOA的数据很少。主动脉球囊阻断(ABO)创伤登记处旨在收集所有出血性休克创伤患者的数据,这些患者的治疗包括放置REBOA。在ABO登记处纳入的所有患者中,72例存在严重骨盆损伤,是研究人群。66.7%为男性。平均和中位数损伤严重度评分(ISS)分别为43和41(标准差±13)。12例患者(16.7%)观察到孤立性骨盆损伤。钝性创伤发生在68例患者(94.4%),穿透性创伤2例(2.8%),复合伤2例(2.8%)。损伤类型:高处坠落15例(23.1%),交通事故49例(75.4%),未明确撞击1例(1.5%)。1例患者在院前获得股动脉入路,43例在急诊室,12例在手术室,16例在血管造影室。REBOA位于1区59例(81.9%),2区1例(1.4%),3区12例(16.7%)。主动脉阻断为部分/间歇性35例(48.6%),完全阻断37例(51.4%)。REBOA相关发病率为11.1%。总死亡率为54.2%,早期死亡率(≤24小时)为44.4%。单因素分析中,与早期死亡率(≤24小时)相关的因素有较低的pH值(p = 0.03)、较高的碱缺失(p = 0.021)、较长的国际标准化比值(INR)(p = 0.012)、REBOA充气后收缩压升高较小(p = 0.03)以及主动脉完全阻断(p = 0.008)。在多因素分析中,这些值均无显著性差异。在严重血流动力学不稳定骨盆创伤的管理中,REBOA在经验丰富的中心作为其他治疗的桥梁使用时是一种可行的选择;然而,其使用可能伴随着严重至致命的并发症。

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