肺原发性肉瘤——26 例临床病理特征的预后价值。

Primary Sarcoma of the Lung - Prognostic Value of Clinicopathological Characteristics of 26 Cases.

机构信息

Fourth Department of Internal Medicine - Hematology Oncology Unit, Attikon University General Hospital, National and Kapodistrian University of Athens, Athens, Greece

1st Medical Oncology Clinic, Saint-Savvas Anticancer Hospital, Athens, Greece.

出版信息

Anticancer Res. 2020 Mar;40(3):1697-1703. doi: 10.21873/anticanres.14122.

DOI:10.21873/anticanres.14122

PMID:32132077

Abstract

BACKGROUND/AIM: Primary sarcomas of the lung (PSL) represent a rare, largely unknown entity. We herein present a retrospective study of 26 patients diagnosed with PSL.

PATIENTS AND METHODS

For a period of 10 years, the records of patients from 5 centers were gathered and analyzed.

RESULTS

Median age at diagnosis was 61.96 years (range=31-75 years). Eight patients (33.33%) had mediastinal node invasion (MNI). From 17 patients (70.83%) with localized disease, 11 patients (64.70%) underwent surgery. Recurrence rate was 72.72%. Median disease-free interval was 15 months. The median overall survival (OS) of patients with metastatic disease was 4 months and 10 months for the whole population. Only surgery had an impact on survival.

CONCLUSION

Prognosis of PSL is somber. The high proportion of patients with MNI at diagnosis may serve as an indication for surgical evaluation of mediastinum and raises the question whether patients with locoregional PSL should be treated with a more aggressive approach.

摘要

背景/目的：肺原发性肉瘤（PSL）是一种罕见且知之甚少的疾病。本研究回顾性分析了 26 例 PSL 患者的临床资料。

方法

对 5 个中心的患者进行为期 10 年的随访，并对其资料进行分析。

结果

诊断时的中位年龄为 61.96 岁（范围为 31-75 岁）。8 例患者（33.33%）有纵隔淋巴结侵犯（MNI）。17 例局限性疾病患者中，11 例（64.70%）接受了手术治疗。复发率为 72.72%。无疾病间期的中位数为 15 个月。转移性疾病患者的中位总生存期（OS）为 4 个月，而整个患者群体的 OS 为 10 个月。只有手术对生存有影响。