商业大麻素油诱发的史蒂文斯-约翰逊综合征。
Commercial Cannabinoid Oil-Induced Stevens-Johnson Syndrome.
作者信息
Yin Han Y, Hadjokas Nicholas, Mirchia Kanish, Swan Robert, Alpert Samuel
机构信息
Department of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.
Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
出版信息
Case Rep Ophthalmol Med. 2020 Feb 19;2020:6760272. doi: 10.1155/2020/6760272. eCollection 2020.
PURPOSE
To report an unusual presentation of commercial cannabidiol (CBD) oil-induced Stevens-Johnson Syndrome/toxic epidermal necrolysis (SJS-TEN).
METHODS
A 56-year-old woman presented with acute onset of a diffuse, blistering, maculopapular rash with over 30% total body surface area (BSA) involvement two days after taking CBD oil sublingually for chronic pain. Biopsy confirmed SJS-TEN. Ophthalmology was consulted and mild eye involvement was found. She was started on topical cyclosporine, prednisone, moxifloxacin, and erythromycin ointment to prevent progression, which was successful. She was otherwise treated with supportive therapy in the intensive care burn unit and ultimately passed away from septic shock.
CONCLUSION
In this case, we described an unusual drug-induced SJS from a commercial, non-FDA-regulated cannabis product. The use of a commercial CBD product should be cautioned due to potential for series of drug reactions to the cannabis product and the risk for reaction to other unregulated other pharmacological components.
目的
报告一例罕见的由商用大麻二酚（CBD）油诱发的史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症（SJS-TEN）。
方法
一名56岁女性，因慢性疼痛舌下含服CBD油两天后，突发弥漫性、水疱性、斑丘疹皮疹，累及全身表面积（BSA）超过30%。活检确诊为SJS-TEN。咨询眼科后发现轻度眼部受累。开始局部使用环孢素、泼尼松、莫西沙星和红霉素眼膏以防止病情进展，治疗成功。她在重症监护烧伤病房接受了其他支持治疗，最终因感染性休克去世。
结论
在本病例中，我们描述了一种由非美国食品药品监督管理局（FDA）监管的商用大麻产品引起的罕见药物性SJS。由于大麻产品可能引发一系列药物反应以及对其他未监管的药理成分产生反应的风险，使用商用CBD产品应谨慎。
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