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Efficacy of a Low-Cost, Heat-Stable Oral Rotavirus Vaccine in Niger.低成本、热稳定型口服轮状病毒疫苗在尼日尔的疗效。
N Engl J Med. 2017 Mar 23;376(12):1121-1130. doi: 10.1056/NEJMoa1609462.
2
Adherence to recommendations on lipid-based nutrient supplement and iron and folic acid tablet consumption among pregnant and lactating women participating in a community health programme in northwest Bangladesh.孟加拉国西北部参与社区健康项目的孕妇和哺乳期妇女对脂质营养补充剂以及铁和叶酸片服用建议的依从性。
Matern Child Nutr. 2017 Jan;13(1). doi: 10.1111/mcn.12252. Epub 2016 Feb 22.
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Lipid-based nutrient supplements for pregnant women reduce newborn stunting in a cluster-randomized controlled effectiveness trial in Bangladesh.在孟加拉国进行的一项整群随机对照有效性试验中,孕妇使用的脂质营养补充剂可减少新生儿发育迟缓情况。
Am J Clin Nutr. 2016 Jan;103(1):236-49. doi: 10.3945/ajcn.115.111336. Epub 2015 Nov 25.
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Acceptability of Novel Small-Quantity Lipid-Based Nutrient Supplements for Complementary Feeding in a Peri-Urban South African Community.新型小剂量脂质基营养补充剂在南非城郊社区用于辅食喂养的可接受性
Food Nutr Bull. 2015 Dec;36(4):455-66. doi: 10.1177/0379572115616057. Epub 2015 Nov 8.
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Informing a Behavior Change Communication Strategy: Formative Research Findings From the Scaling Up Nutrition Movement in Mozambique.为行为改变沟通策略提供信息:莫桑比克扩大营养运动的形成性研究结果
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Malawian Mothers Consider Lipid-Based Nutrient Supplements Acceptable for Children throughout a 1-Year Intervention, but Deviation from User Recommendations Is Common.马拉维母亲认为在为期一年的干预期间,基于脂质的营养补充剂对儿童来说是可以接受的,但偏离用户建议的情况很常见。
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Acceptability of new formulations of corn-soy blends and lipid-based nutrient supplements in Province du Passoré, Burkina Faso.布基纳法索帕索雷省玉米-大豆混合食品和脂质基营养补充剂新配方的可接受性
Appetite. 2015 Aug;91:278-86. doi: 10.1016/j.appet.2015.04.058. Epub 2015 Apr 23.
9
Intervention strategies to address multiple micronutrient deficiencies in pregnancy and early childhood.解决孕期和幼儿期多种微量营养素缺乏问题的干预策略。
Nestle Nutr Inst Workshop Ser. 2012;70:61-73. doi: 10.1159/000337441. Epub 2012 Aug 31.
10
The impact of lipid-based nutrient supplement provision to pregnant women on newborn size in rural Malawi: a randomized controlled trial.农村马拉维孕妇补充脂类营养素对新生儿大小的影响:一项随机对照试验。
Am J Clin Nutr. 2015 Feb;101(2):387-97. doi: 10.3945/ajcn.114.088617. Epub 2014 Dec 10.

为尼日尔农村地区孕妇配制的脂质营养补充剂的可接受性和利用率:一项多方法研究。

Acceptability and utilization of a lipid-based nutrient supplement formulated for pregnant women in rural Niger: a multi-methods study.

作者信息

Isanaka Sheila, Kodish Stephen R, Mamaty Abdoul Aziz, Guindo Ousmane, Zeilani Mamane, Grais Rebecca F

机构信息

1Epicentre, 8 rue Saint Sabin, 75011 Paris, France.

2Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA 02115 USA.

出版信息

BMC Nutr. 2019 Jul 1;5:34. doi: 10.1186/s40795-019-0298-3. eCollection 2019.

DOI:10.1186/s40795-019-0298-3
PMID:32153947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7050705/
Abstract

BACKGROUND

In food insecure settings, it may be difficult for pregnant women to meet increased nutritional needs through traditional diets. A promising new strategy to fill nutrient gaps in pregnancy involves the provision of lipid-based nutrient supplements (LNS). We aimed to assess the acceptability and utilization of a 40 g LNS formulation (Epi-E) with increased micronutrient content relative to the recommended daily allowance among pregnant women in rural Niger.

METHODS

We conducted a two-part, multi-methods study among pregnant women presenting to antenatal care in Madarounfa, Niger during two periods (Ramadan and non-Ramadan). Part 1 included two LNS test meals provided at the health center, and Part 2 included a 14-day home trial to simulate more realistic conditions outside of the health center. Open- and closed-ended questions were used to assess organoleptic properties of Epi-E using a 5-point hedonic scale after the test meals, as well as utilization and willingness to pay for Epi-E after the 14-day home trial.

RESULTS

Participants consumed more than 90% of the test meal in both periods. Epi-E was rated highly in terms of overall liking, color, taste and smell during test meals in both periods (median 5/5 for all); only time, mode and frequency of consumption varied between Ramadan and non-Ramadan periods in observance of daily fasting during the holy month.

CONCLUSION

Epi- E, a 40 g LNS formulation with increased micronutrient content, was highly acceptable among pregnant women in rural Niger, and utilization was guided by household and individual considerations that varied by time period. This formulation can be further tested as a potential strategy to improve the nutritional status of pregnant women in this context.

TRIAL REGISTRATION

ClinicalTrials.gov Identifier: NCT02145000. Registered 22 May 2014.

摘要

背景

在粮食不安全地区,孕妇可能难以通过传统饮食满足增加的营养需求。一种有前景的填补孕期营养缺口的新策略是提供基于脂质的营养补充剂(LNS)。我们旨在评估一种40克的LNS制剂(Epi-E)在尼日尔农村孕妇中的可接受性和利用率,该制剂相对于推荐每日摄入量增加了微量营养素含量。

方法

我们在尼日尔马达鲁恩法的两个时期(斋月和非斋月)对前来接受产前护理的孕妇进行了一项两部分的多方法研究。第1部分包括在健康中心提供的两份LNS测试餐,第2部分包括为期14天的家庭试验,以模拟健康中心以外更现实的情况。在测试餐后,使用开放式和封闭式问题,通过5分喜好量表评估Epi-E的感官特性,在为期14天的家庭试验后评估Epi-E的利用率和支付意愿。

结果

在两个时期,参与者均食用了超过90%的测试餐。在两个时期的测试餐期间,Epi-E在总体喜好、颜色、味道和气味方面的评分都很高(所有方面的中位数均为5/5);在斋月期间,仅食用时间、方式和频率因遵守每日禁食而在斋月和非斋月期间有所不同。

结论

Epi-E是一种40克的LNS制剂,微量营养素含量增加,在尼日尔农村孕妇中高度可接受,其使用受家庭和个人因素的指导,这些因素因时期而异。在这种情况下,这种制剂可作为改善孕妇营养状况的潜在策略进行进一步测试。

试验注册

ClinicalTrials.gov标识符:NCT02145000。2014年5月22日注册。