伊马替尼新辅助治疗后食管胃肠道间质瘤手术切除1例
[A Case of Surgical Resection of an Esophageal Gastrointestinal Stromal Tumor after Neoadjuvant Therapy with Imatinib].
作者信息
Nishida Yuki, Takeda Shigeru, Kanekiyo Shinsuke, Shindo Yoshitaro, Matsukuma Satoshi, Matsui Hiroto, Tokumitsu Yukio, Tomochika Shinobu, Iida Michihisa, Suzuki Nobuaki, Yoshino Shigefumi, Hazama Shoichi, Ueno Tomio, Nagano Hiroaki
机构信息
Dept. of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University, Graduate School of Medicine.
出版信息
Gan To Kagaku Ryoho. 2019 Dec;46(13):2449-2451.
A 64-year-old man presented with dysphagia. Esophagogastroduodenoscopy revealed a submucosal tumor of 52mm in size at the lower thoracic esophagus. Biopsy yielded a pathological diagnosis of c-kit-positive esophageal gastrointestinal stromal tumor(GIST). We started neoadjuvant therapy with imatinib to avoid excessive surgical invasion. After 6 months of treatment, CT revealed a reduction in tumor size to 27 mm. We performed laparoscopic lower esophagectomy, proximal gastrectomy, double-tract reconstruction, and complete tumor resection. Neoadjuvant imatinib therapy was effective for the esophageal GIST.
一名64岁男性因吞咽困难就诊。食管胃十二指肠镜检查发现胸段食管下段有一个大小为52mm的黏膜下肿瘤。活检病理诊断为c-kit阳性食管胃肠道间质瘤（GIST）。为避免过度手术侵袭，我们开始使用伊马替尼进行新辅助治疗。治疗6个月后，CT显示肿瘤大小缩小至27mm。我们进行了腹腔镜下食管下段切除术、近端胃切除术、双通道重建及肿瘤完整切除。伊马替尼新辅助治疗对食管GIST有效。
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