Pantò Felicia, Adamo Liboria, Giordano Carla, Licciardello Carmelo
Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine, University of Palermo, Palermo, Italy.
Unit of Metabolic and Endocrine Diseases, Centro Catanese di Medicina e Chirurgia, Catania, Italy.
Drugs Context. 2020 Feb 10;9. doi: 10.7573/dic.2019-10-3. eCollection 2020.
This article is the second part of a literature review concerning diabetic foot ulcers (DFUs) and the use of antimicrobial photodynamic therapy (PDT). PDT involves the topical application of a photosensitiser into the tissue, followed by illumination that induces the formation of reactive oxygen species (ROS). PDT provides bacterial inactivation and promotes wound healing, and it can be used to manage the infection and microbial colonisation of DFUs. It has pivotal advantages in comparison with chemotherapeutics, such as no potential to induce resistance, and a wide spectrum of activity. Tetracationic Zn(II) phthalocyanine derivatives have been developed for PDT. Among these, we would like to focus on RLP068, whose antimicrobial activity has been widely demonstrated in preclinical studies and in a clinical trial. This article reports previously published evidence and presents four unpublished clinical cases of DFUs treated in the real-life setting with PDT.
本文是关于糖尿病足溃疡（DFU）及抗菌光动力疗法（PDT）应用的文献综述的第二部分。光动力疗法包括将光敏剂局部应用于组织，随后进行光照以诱导活性氧（ROS）的形成。光动力疗法可使细菌失活并促进伤口愈合，可用于处理糖尿病足溃疡的感染和微生物定植。与化学疗法相比，它具有关键优势，如无诱导耐药性的可能性以及广泛的活性谱。四价锌（II）酞菁衍生物已被开发用于光动力疗法。其中，我们将重点关注RLP068，其抗菌活性已在临床前研究和一项临床试验中得到广泛证实。本文报告了先前发表的证据，并展示了4例在现实环境中接受光动力疗法治疗的糖尿病足溃疡未发表的临床病例。
