Department of Obstetrics and Gynecology, University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA.
University of Rochester, School of Medicine and Dentistry, Rochester, NY, USA.
Investig Clin Urol. 2020 Mar;61(2):231-237. doi: 10.4111/icu.2020.61.2.231. Epub 2020 Jan 29.
The aim of this study is to evaluate changes in sleep disturbance following treatment of overactive bladder with sacral neuromodulation.
This is a sub-analysis of data collected from an institutional review board approved retrospective cohort study evaluating women with Patient-Reported Outcomes Measurement Information System-Sleep Disturbance (PROMIS-SD) before and after sacral neuromodulation for overactive bladder between March 2016 and October 2017. Data collected included demographics, clinical characteristics, and additional PROMIS item banks. Within-group analysis was performed with paired t-tests. Groups based up on PROMIS-SD improvement (change <0) were then compared using Fisher's exact test, t-test, or Mann-Whitney U-test as appropriate.
Those with improved sleep disturbance (n=7) noted a significant mean improvement of -3.99 (95% confidence interval, -6.32, -1.65; p<0.01). Both pre- and post-procedure PROMIS-Physical Function (38.86±2.35 vs. 34.13±5.58, p=0.07 and 37.14±5.10 vs. 35.44±4.74, p=0.53), Pain Interference (60.04±6.34 vs. 65.50±6.20, p=0.13 and 57.89±5.08 vs. 64.73±7.35, p=0.07), Depression (44.2±4.73 vs. 61.29±9.53, p=0.17 and 54.29±6.25 vs. 57.96±11.42, p=0.47) t-scores were similar between sleep response groups.
Those with improved sleep disturbance reported significant changes after sacral neuromodulation for overactive bladder. However, no significant differences were identified between those with and without improvement. Further investigation of changes in sleep disturbance and factors affecting change are needed within this population.
本研究旨在评估骶神经调节治疗膀胱过度活动症后睡眠障碍的变化。
这是一项从机构审查委员会批准的回顾性队列研究中收集的数据的亚分析，该研究评估了 2016 年 3 月至 2017 年 10 月间因膀胱过度活动症接受骶神经调节的女性患者的患者报告结局测量信息系统-睡眠障碍（PROMIS-SD）的前后变化。收集的数据包括人口统计学、临床特征和其他 PROMIS 项目库。采用配对 t 检验进行组内分析。然后根据 PROMIS-SD 改善（变化<0）将患者分为两组，并使用 Fisher 确切检验、t 检验或 Mann-Whitney U 检验进行比较。
睡眠障碍改善的患者（n=7）的平均改善值为-3.99（95%置信区间：-6.32，-1.65；p<0.01）。治疗前后 PROMIS 身体功能（38.86±2.35 与 34.13±5.58，p=0.07 和 37.14±5.10 与 35.44±4.74，p=0.53）、疼痛干扰（60.04±6.34 与 65.50±6.20，p=0.13 和 57.89±5.08 与 64.73±7.35，p=0.07）、抑郁（44.2±4.73 与 61.29±9.53，p=0.17 和 54.29±6.25 与 57.96±11.42，p=0.47）t 评分在睡眠反应组之间相似。
睡眠障碍改善的患者在接受骶神经调节治疗膀胱过度活动症后报告有显著变化。然而，在有改善和无改善的患者之间没有发现显著差异。需要在这一人群中进一步研究睡眠障碍的变化和影响变化的因素。
