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经导管主动脉瓣置换术后能否减少传导障碍?

Can we reduce conduction disturbances following transcatheter aortic valve replacement?

机构信息

Quebec Heart & Lung Institute, Laval University, Quebec City, QC, Canada.

出版信息

Expert Rev Med Devices. 2020 Apr;17(4):309-322. doi: 10.1080/17434440.2020.1741349. Epub 2020 Mar 27.

Abstract

: Transcatheter aortic valve replacement (TAVR) has been demonstrated to be a good alternative to surgery for treating severe aortic stenosis (AS) across the whole range of surgical risk patients. Whereas most periprocedural TAVR complications have significantly decreased over time, conduction disturbances remain high. Approaches to decrease this shortcoming are under continuous investigation.: Overview of the actual evidence regarding conduction disturbances in the TAVR setting, focusing on modifiable factors. PubMed and Embase databases were used for literature search.: Several factors have been associated with an increased risk of conduction disturbances post-TAVR, and some of them may be modifiable. While some transcatheter valve systems have been associated with higher rates of conduction disturbances, additional randomized data are needed to draw definite conclusions about newer generation transcatheter valve systems. Nowadays, good hemodynamic valve function can be obtained without excessive valve oversizing, which has been associated with an increased risk of conduction disturbances in some studies. Also, contemporary data regarding valve implantation depth and new anatomical landmarks such as membranous septum length have provided valuable insights for procedural planning. Finally, homogenization of the management of conduction abnormalities post-TAVR should be emphasized to allow a better understanding and generalization of available evidence.

摘要

经导管主动脉瓣置换术(TAVR)已被证明是治疗各种手术风险患者严重主动脉瓣狭窄(AS)的一种很好的替代方法。虽然大多数围手术期 TAVR 并发症随着时间的推移已经显著减少,但传导障碍仍然很高。目前正在不断研究降低这一缺陷的方法。

本文综述了 TAVR 环境中传导障碍的现有证据,重点关注可修正的因素。使用 PubMed 和 Embase 数据库进行文献检索。

一些因素与 TAVR 后传导障碍的风险增加有关,其中一些因素可能是可修正的。虽然一些经导管瓣膜系统与更高的传导障碍发生率相关,但需要更多的随机数据来对新一代经导管瓣膜系统得出明确的结论。如今,在不进行过度瓣膜扩大的情况下,也可以获得良好的血流动力学瓣膜功能,而一些研究表明,瓣膜扩大与传导障碍的风险增加有关。此外,关于瓣膜植入深度和新的解剖学标志(如膜间隔长度)的最新数据为手术规划提供了有价值的见解。最后,应强调 TAVR 后传导异常管理的同质化,以便更好地理解和推广现有证据。

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