Suppr超能文献

30例新型冠状病毒肺炎感染医护人员的临床特征

[Clinical characteristics of 30 medical workers infected with new coronavirus pneumonia].

作者信息

Liu M, He P, Liu H G, Wang X J, Li F J, Chen S, Lin J, Chen P, Liu J H, Li C H

机构信息

Department of Respiratory and Critical Care Medicine, the Affiliated Hospital of Jianghan University, Wuhan430015, China.

Department of geriatrics, the Affiliated Hospital of Jianghan University, Wuhan430015, China.

出版信息

Zhonghua Jie He He Hu Xi Za Zhi. 2020 Mar 12;43(3):209-214. doi: 10.3760/cma.j.issn.1001-0939.2020.03.014.

Abstract

To investigate the clinical characteristics of medical staff with novel coronavirus pneumonia(NCP). 30 patients infected with novel coronavirus referred to jianghan university hospital between January 11, 2020 and January 3, 2020 were studied. The data reviewed included those of clinical manifestations, laboratory investigation and Radiographic features. The patients consisted of 10 men and 20 women, including 22 doctors and 8 nurses,aged 21~59 years(mean 35±8 years).They were divided to 26 common type and 4 severe cases, all of whom had close(within 1m) contact with patients infected of novel coronavirus pneumonia. The average contact times were 12 (7,16) and the average cumulative contact time was 2 (1.5,2.7) h.Clinical symptoms of these patients were fever in 23 patients (76.67%) , headache in 16 petients (53.33%) , fatigue or myalgia in 21patients (70%) , nausea, vomiting or diarrhea in 9 petients (30%) , cough in 25 petients (83.33%) , and dyspnea in 14 petients (46.67%) .Routine blood test revealed WBC<4.0×10(9)/L in 8 petients (26.67%) , (4-10) ×10(9)/L in 22 petients (73.33%) , and WBC>4.0×10(9)/L in 4 petients (13.33%) during the disease.Lymphocyte coun1.0×10(9)/L occurred in 12 petients (40%),abnormal liver function in 7 petients (23.33%) ,myocardial damage in 5 petients(16.67%), elevated D-dimer (>0.5mg/l) in 5 patients (16.67%). Compared with normal patients, the average exposure times, cumulative exposure time, BMI, Fever time, white blood cell count, liver enzyme, LDH, myoenzyme and D-dimer were significantly increased in severe patients, while the lymphocyte count and albumin levels in peripheral blood were significantly decreased.Chest CT mainly showed patchy shadows and interstitial changes.According to imaging examination, 11 patients (36.67%) showed Unilateral pneumonia and 19 patients (63.33%) showed bilateral pneumonia,4 patients (13.33%) showed bilateral multiple mottling and ground-glass opacity.Compared with the patients infected in the protected period, the proportion of severe infection and bilateral pneumonia were both increased in the patients infected in unprotected period. Medical staffs are at higher risk of infection.Infection rates are associated with contact time, the amount of suction virus. Severe patients had BMI increased, heating time prolonged, white blood cell count, lymphocyte count, D-dimer and albumin level significantly changed and were prone to be complicated with liver damage and myocardial damage.Strict protection measures is important to prevent infection for medical workers.

摘要

为调查新型冠状病毒肺炎(NCP)医护人员的临床特征,对2020年1月11日至2020年1月3日转诊至江汉大学附属医院的30例新型冠状病毒感染患者进行了研究。回顾的数据包括临床表现、实验室检查和影像学特征。患者包括10名男性和20名女性,其中医生22名,护士8名,年龄21至59岁(平均35±8岁)。他们被分为26例普通型和4例重型,均与新型冠状病毒肺炎感染患者有密切(1米内)接触。平均接触次数为12(7,16)次,平均累计接触时间为2(1.5,2.7)小时。这些患者的临床症状为发热23例(76.67%)、头痛16例(53.33%)、乏力或肌痛21例(70%)、恶心、呕吐或腹泻9例(30%)、咳嗽25例(83.33%)、呼吸困难14例(46.67%)。血常规检查显示,病程中8例(26.67%)白细胞<4.0×10⁹/L,22例(73.33%)白细胞在(4 - 10)×10⁹/L之间,4例(13.33%)白细胞>4.0×10⁹/L。12例(40%)淋巴细胞计数<1.0×10⁹/L,7例(23.33%)肝功能异常,5例(16.67%)心肌损伤,5例(16.67%)D - 二聚体升高(>0.5mg/l)。与正常患者相比,重型患者的平均暴露次数、累计暴露时间、BMI、发热时间、白细胞计数、肝酶、乳酸脱氢酶、肌酶和D - 二聚体显著升高,而外周血淋巴细胞计数和白蛋白水平显著降低。胸部CT主要表现为斑片状阴影和间质改变。根据影像学检查,11例(36.67%)表现为单侧肺炎,19例(63.33%)表现为双侧肺炎,4例(13.33%)表现为双侧多发斑片及磨玻璃影。与在防护期感染的患者相比,未防护期感染的患者中重型感染和双侧肺炎的比例均增加。医护人员感染风险较高。感染率与接触时间、吸入病毒量有关。重型患者BMI增加、发热时间延长、白细胞计数、淋巴细胞计数、D - 二聚体及白蛋白水平有显著变化,且易并发肝损伤和心肌损伤。严格的防护措施对预防医护人员感染很重要。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验