HIV Unit, Hospital Universitario 12 De Octubre - Imas12, Madrid, Spain.
Expert Rev Anti Infect Ther. 2020 May;18(5):393-404. doi: 10.1080/14787210.2020.1736561. Epub 2020 Mar 12.
: Antiretroviral treatment (ART) has led to improved control of HIV infection, giving the opportunity of exploring therapeutic alternatives as new long-acting (LA) regimens, that might improve the quality of life of people living with HIV (PLWH).: This article overviews the pharmacokinetic and pharmacodynamic properties of LA cabotegravir and rilpivirine (CR), two nanoformulated drugs of intramuscular administration and focuses on assessing its role on the treatment of HIV infection.: In addition to the advantage of treatment simplification, which could be especially beneficial for population subgroups with significant HIV-related stigma, it also reduces the number of drugs, and probably, the risk of treatment-related toxicity. The similar efficacy when compared to oral triple therapies in clinical trials and the high satisfaction rates among both professionals and patients make LA CR a suitable alternative for the control of HIV infection in the modern era.
: 抗逆转录病毒治疗（ART）已改善了对 HIV 感染的控制，为探索新的长效（LA）方案提供了机会，这可能会提高 HIV 感染者（PLWH）的生活质量。本文综述了 LA 卡替拉韦和利匹韦林（CR）的药代动力学和药效学特性，这两种药物为肌肉内给药的纳米制剂，并重点评估了其在 HIV 感染治疗中的作用。除了治疗简化的优势，这对具有显著 HIV 相关耻辱感的亚人群可能特别有益外，它还减少了药物的数量，并且可能降低了与治疗相关的毒性的风险。临床试验中与口服三联疗法的疗效相当，以及专业人员和患者的高满意度，使 LA CR 成为控制现代 HIV 感染的一种合适选择。
