National Research University "MPEI", Moscow, Russia.
Penza State University, Penza, Russia.
BMC Bioinformatics. 2020 Mar 11;21(Suppl 2):87. doi: 10.1186/s12859-020-3354-8.
The actual task of electrocardiographic examinations is to increase the reliability of diagnosing the condition of the heart. Within the framework of this task, an important direction is the solution of the inverse problem of electrocardiography, based on the processing of electrocardiographic signals of multichannel cardio leads at known electrode coordinates in these leads (Titomir et al. Noninvasiv electrocardiotopography, 2003), (Macfarlane et al. Comprehensive Electrocardiology, 2nd ed. (Chapter 9), 2011).
In order to obtain more detailed information about the electrical activity of the heart, we carry out a reconstruction of the distribution of equivalent electrical sources on the heart surface. In this area, we hold reconstruction of the equivalent sources during the cardiac cycle at relatively low hardware cost. ECG maps of electrical potentials on the surface of the torso (TSPM) and electrical sources on the surface of the heart (HSSM) were studied for different times of the cardiac cycle. We carried out a visual and quantitative comparison of these maps in the presence of pathological regions of different localization. For this purpose we used the model of the heart electrical activity, based on cellular automata.
The model of cellular automata allows us to consider the processes of heart excitation in the presence of pathological regions of various sizes and localization. It is shown, that changes in the distribution of electrical sources on the surface of the epicardium in the presence of pathological areas with disturbances in the conduction of heart excitation are much more noticeable than changes in ECG maps on the torso surface.
心电图检查的实际任务是提高诊断心脏状况的可靠性。在这个任务的框架内,一个重要的方向是解决心电图的逆问题,基于在这些导联中已知电极坐标的多通道心电导联的心电图信号处理(Titomir 等人,非侵入性心电拓扑学,2003 年),(Macfarlane 等人,综合心电图学,第二版(第 9 章),2011 年)。
为了获得关于心脏电活动的更详细信息,我们进行了心脏表面等效电源分布的重建。在这个区域,我们以相对较低的硬件成本在心脏周期内进行等效源的重建。研究了心脏周期不同时间的躯体表面心电图电位图(TSPM)和心脏表面电源图(HSSM)。我们对这些地图进行了视觉和定量比较,在存在不同定位的病理区域的情况下。为此,我们使用了基于元胞自动机的心脏电活动模型。
元胞自动机模型允许我们考虑在存在各种大小和定位的病理区域的情况下心脏兴奋的过程。结果表明,在存在心脏兴奋传导障碍的病理区域时,心外膜表面电源分布的变化比躯体表面心电图图的变化更为明显。