尿苷分解打破了共生关系的束缚。

Uridine Catabolism Breaks the Bonds of Commensalism.

机构信息

Aix Marseille Université, CNRS, IBDM-UMR7288, Turing Center for Living Systems, 13009 Marseille, France.

Aix Marseille Université, CNRS, IBDM-UMR7288, Turing Center for Living Systems, 13009 Marseille, France; Institut Universitaire de France, Paris, France.

出版信息

Cell Host Microbe. 2020 Mar 11;27(3):312-314. doi: 10.1016/j.chom.2020.02.008.

DOI:10.1016/j.chom.2020.02.008

PMID:32164840

Abstract

How gut cells distinguish between beneficial symbionts and deleterious pathobionts is a central question. In this issue of Cell Host & Microbe, Kim et al. (2020) demonstrate that the nucleoside catabolism pathway controlling bacterial uracil and ribose production is an essential trigger of the commensal to pathogen transition.

摘要

肠道细胞如何区分有益共生体和有害的条件致病菌是一个核心问题。在本期《细胞宿主与微生物》中，Kim 等人（2020）证明了控制细菌尿嘧啶和核糖产生的核苷分解代谢途径是共生体向病原体转变的一个必要触发因素。