First Department of Dermatology and Venereology, "Andreas Syggros" Hospital, National and Kapodistrian University of Athens, Medical School, Ionos Dragoumi 5, 11621, Athens, Greece.
First Department of Pediatrics, Choremeio Research Laboratory, National and Kapodistrian University of Athens, Thivon & Levadeias 8, 11527, Goudi, Athens, Greece.
Endocr Metab Immune Disord Drug Targets. 2020;20(10):1726-1739. doi: 10.2174/1871530320666200313151720.
Chronic spontaneous urticaria (CSU, or CU) is a disease that significantly affects the quality of life of patients. It is a chronic disease and requires a specialized approach to diagnosis and treatment. In recent years, the disease has been of great interest due to the existence of new targeted therapeutic approaches.
The present study aims at analyzing CU score concerning time, as a time-series. The authors have attempted to model the investigated time-series to unravel possible causative relationships.
108 patients (25Males/83Females) admitted to our department were diagnosed with CU. CU was estimated on a score basis, which was used to define disease severity. Urticaria score was assessed on the basis of Urticaria Activity Score 7 (UAS7). The mean CU score, the mean CU score rate concerning the first month at diagnosis as well as the monthly CU score rate were calculated.
Gender is a factor that influences CU score with time. In addition, there was a significant finding that time-series differ with the administration of monotherapy or complementary therapy.
We have found that females are more prone to CU, while omalizumab monotherapy has more beneficial results as compared to the application of concurrent and maintenance therapies. Further, patients with co-morbidities were more likely to interrupt treatment. Finally, and most significantly, it was shown that monthly CU score rate manifested an oscillatory pattern, which was modelled with the sum of sines functions, highlighting a relative immunological pattern.
慢性自发性荨麻疹（CSU，或 CU）是一种严重影响患者生活质量的疾病。它是一种慢性病，需要专门的方法进行诊断和治疗。近年来，由于存在新的靶向治疗方法，该疾病引起了极大的关注。
本研究旨在分析 CU 评分随时间的变化，作为时间序列。作者试图对所研究的时间序列进行建模，以揭示可能的因果关系。
我们部门收治了 108 名患者（25 名男性/83 名女性），诊断为 CU。CU 采用评分进行评估，用于定义疾病严重程度。荨麻疹评分基于荨麻疹活动评分 7（UAS7）进行评估。计算 CU 平均评分、诊断后第一个月的 CU 平均评分率以及每月 CU 评分率。
性别是影响 CU 评分随时间变化的一个因素。此外，还有一个重要发现，即时间序列因单一疗法或补充疗法的应用而有所不同。
我们发现女性更容易患 CU，而奥马珠单抗单药治疗比联合和维持治疗的效果更好。此外，合并症患者更有可能中断治疗。最后，也是最重要的一点，表明每月 CU 评分率表现出振荡模式，通过正弦函数的和进行建模，突出了相对免疫模式。
