代谢手术后口服葡萄糖耐量试验后胰多肽激素水平的变化：胃旁路术与袖状胃切除术的比较。

Changes in post-oral glucose challenge pancreatic polypeptide hormone levels following metabolic surgery: A comparison of gastric bypass and sleeve gastrectomy.

机构信息

School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, Taiwan.

Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, Taiwan; Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan.

出版信息

Neuropeptides. 2020 Jun;81:102032. doi: 10.1016/j.npep.2020.102032. Epub 2020 Feb 27.

DOI:10.1016/j.npep.2020.102032

PMID:32169256

Abstract

BACKGROUND

Pancreatic polypeptide (PP) hormone is a 36-amino-acid peptide released from the pancreas, the serum levels of which have been shown to rise upon food intake. The underlying mechanism for metabolic surgery in the treatment of patients with type 2 diabetes mellitus (T2DM) remains intriguing. We compared post-oral glucose challenge PP levels between patients undergoing laparoscopic gastric bypass (GB) and sleeve gastrectomy (SG) at 1 year after surgery.

METHODS

This hospital-based, prospective study followed up a total of 12 laparoscopic GB and 12 laparoscopic SG patients and evaluated their glucose homeostasis. One year after metabolic surgery, 75-g oral glucose tolerance tests (OGTTs) were performed in the patients in the GB and SG groups and the blood levels of PP were evaluated.

RESULTS

The laparoscopic GB group had stable serum PP levels within 120 min after OGTT; however, the levels were significantly higher in the laparoscopic SG group at 30 min after OGTT. The patients with complete T2DM remission did not exhibit significantly different PP levels at fasting and post-OGTT than those in patients without remission after GB. Similarly, after SG, patients with T2DM remission did not show significantly different PP levels at fasting and post-OGTT than those in patients without T2DM remission.

CONCLUSIONS

No significant difference was found in plasma PP levels after OGTT in T2DM patients that received either GB or SG, or in T2DM remitters or non-remitters 1 year after metabolic surgery.

摘要

背景

胰多肽（PP）激素是一种由胰腺释放的 36 个氨基酸肽，其血清水平在进食后会升高。代谢手术治疗 2 型糖尿病（T2DM）的潜在机制仍然令人着迷。我们比较了腹腔镜胃旁路术（GB）和袖状胃切除术（SG）治疗 1 年后患者口服葡萄糖耐量试验（OGTT）后 PP 水平。

方法

这是一项基于医院的前瞻性研究，共随访了 12 例腹腔镜 GB 和 12 例腹腔镜 SG 患者，并评估了他们的葡萄糖稳态。代谢手术后 1 年，对 GB 和 SG 组患者进行 75g 口服葡萄糖耐量试验（OGTT），并评估 PP 血水平。

结果

腹腔镜 GB 组 OGTT 后 120min 内血清 PP 水平稳定；然而，腹腔镜 SG 组 OGTT 后 30min 时水平显著升高。完全缓解 T2DM 的患者在 OGTT 前后的空腹和餐后 PP 水平与未缓解的患者无显著差异。同样，SG 后，T2DM 缓解患者在 OGTT 前后的空腹和餐后 PP 水平与未缓解的患者无显著差异。