Janiri Delfina, Doucet Gaelle E, Pompili Maurizio, Sani Gabriele, Luna Beatriz, Brent David A, Frangou Sophia
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy; Centro Lucio Bini-Aretæus, Rome, Italy.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lancet Psychiatry. 2020 Apr;7(4):317-326. doi: 10.1016/S2215-0366(20)30049-3. Epub 2020 Mar 12.
Childhood suicidal ideation and behaviours are poorly understood. We examined correlates of suicidality in a US population-based sample of children participating in the Adolescent Brain and Cognitive Development (ABCD) study. The ABCD study aims to examine trajectories of mental health from childhood to adulthood and collects information on multiple domains, including mental and physical wellbeing, brain imaging, behavioural and cognitive characteristics, and social and family environment. We sought to identify and rank risk and protective factors for childhood suicidal thoughts and behaviours across these multiple domains and evaluate their association with self-agreement and caregiver agreement in reporting suicidality.
The ABCD sample comprises a cohort of 11 875 children aged 9-10 years. The sociodemographic factors on which the sample was recruited were age, sex, race, socioeconomic status, and urbanicity. Participants were enrolled at 22 sites, the catchment area of which encompassed over 20% of the entire US population in this age group. Multistage sampling was used to ensure both local randomisation and representativeness of sociodemographic variation of the ABCD sample. The data used in this study were accessed from the ABCD Study Curated Annual Release 2.0. Suicidal thoughts and behaviours (suicidality) in each child were evaluated through independent child and caregiver reports based on the computerized Kiddie Schedule for Affective Disorders and Schizophrenia for DSM-5 (KSADS-5). We used bootstrapped logistic regression to quantify the association between suicidal ideation and behaviours, with measures of mental and physical wellbeing, behaviour, cognition, and social and family environment in participants from the ABCD study.
Our study sample comprised 7994 unrelated children (mean age 9·9 years [SD 0·5]; 4234 [53%] male participants) with complete data on child-reported and caregiver-reported suicidal ideas and behaviours. Overall, 673 (8·4%) children reported any past or current suicidal ideation, 75 (0·9%) had any past or current suicidal plans, and 107 (1·3%) had any past or current suicidal attempts. According to caregivers, 650 (8·1%) of the children reported any past or current suicidal ideation, 46 (0·6%) reported any past or current suicidal plans, and 39 (0·5%) reported past or current suicidal attempts. However, inter-informant agreement was low (Cohen's κ range 0·0-0·2). Regardless of informant, child psychopathology (odds ratio [OR] 1·7-4·8, 95% CI 1·5-7·4) and child-reported family conflict (OR 1·4-1·8, 95% CI 1·1-2·5) were the most robust risk factors for suicidality. The risk of child-reported suicidality increased with higher weekend screen use time (OR 1·3, 95% CI 1·2-1·7) and reduced with greater parental supervision and positive school involvement (for both OR 0·8, 95% CI 0·7-0·9). Additionally, caregiver-reported suicidality was positively associated with caregiver educational level (OR 1·3, 95% CI 1·1-1·5) and male sex in children (1·5, 1·1-2·0), and inversely associated with the number of household cohabitants (0·8, 0·7-1·0).
We identified risk and protective factors that show robust and generalisable associations with childhood suicidality. These factors provide actionable targets for optimising prevention and intervention strategies, support the need to identify and treat psychopathology in school-age children, and underscore the importance of school and family interventions for childhood suicidality.
National Institutes of Health.
儿童自杀意念和行为目前仍未得到充分理解。我们在美国一项基于人群的儿童样本中,研究了参与青少年大脑与认知发展(ABCD)研究的儿童自杀倾向的相关因素。ABCD研究旨在研究从儿童期到成年期的心理健康轨迹,并收集多个领域的信息,包括心理和身体健康、脑成像、行为和认知特征以及社会和家庭环境。我们试图识别并对这些多个领域中儿童自杀想法和行为的风险及保护因素进行排序,并评估它们与报告自杀倾向时的自我一致性和照顾者一致性之间的关联。
ABCD样本包括11875名9至10岁的儿童队列。招募样本所依据的社会人口学因素包括年龄、性别、种族、社会经济地位和城市化程度。参与者在22个地点入组,这些地点的覆盖区域涵盖了该年龄组全美人口的20%以上。采用多阶段抽样以确保ABCD样本在局部的随机性以及社会人口学差异的代表性。本研究中使用的数据来自ABCD研究精选年度版本2.0。通过基于计算机化的适用于《精神疾病诊断与统计手册》第5版(DSM - 5)的儿童情感障碍和精神分裂症量表(KSADS - 5),由儿童和照顾者独立报告,对每个儿童的自杀想法和行为(自杀倾向)进行评估。我们使用自助法逻辑回归来量化自杀意念和行为与ABCD研究参与者的心理和身体健康、行为、认知以及社会和家庭环境指标之间的关联。
我们的研究样本包括7994名无亲属关系的儿童(平均年龄9.9岁[标准差0.5];4234名[53%]为男性参与者),他们有关于儿童报告和照顾者报告的自杀想法及行为的完整数据。总体而言,673名(8.4%)儿童报告有任何过去或当前的自杀意念,75名(0.9%)有任何过去或当前的自杀计划,107名(1.3%)有任何过去或当前的自杀未遂行为。据照顾者报告,650名(8.1%)儿童有任何过去或当前的自杀意念,46名(0.6%)报告有任何过去或当前的自杀计划,39名(0.5%)报告有过去或当前的自杀未遂行为。然而,信息提供者之间的一致性较低(科恩kappa系数范围为0.0 - 0.2)。无论信息提供者如何,儿童精神病理学(优势比[OR]为1.7 - 4.8,95%置信区间为1.5 - 7.4)和儿童报告的家庭冲突(OR为1.4 - 1.8,95%置信区间为1.1 - 2.5)是自杀倾向最显著的风险因素。儿童报告的自杀倾向风险随着周末屏幕使用时间的增加而升高(OR为1.3,95%置信区间为1.2 - 1.7),而随着父母监督的加强和积极的学校参与度而降低(两者OR均为0.8,95%置信区间为0.7 - 0.9)。此外,照顾者报告的自杀倾向与照顾者教育水平呈正相关(OR为1.3,95%置信区间为1.1 - 1.5)以及与儿童中的男性性别呈正相关(1.5,1.1 - 2.0),并且与家庭同居者数量呈负相关(0.8,0.7 - 1.0)。
我们识别出了与儿童自杀倾向具有显著且可推广关联的风险和保护因素。这些因素为优化预防和干预策略提供了可操作的目标,支持了识别和治疗学龄儿童精神病理学的必要性,并强调了学校和家庭干预对儿童自杀倾向的重要性。
美国国立卫生研究院